PRIM1 and RPS26

Data Source:
BioGRID (proximity labelling technology)

		PRIM1	RPS26
Description		DNA primase subunit 1	ribosomal protein S26
Image
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane	Nucleoplasm Cytosol Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Polysomal Ribosome Extracellular Exosome Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane
	Molecular Function	DNA Primase Activity Protein Binding Metal Ion Binding	RNA Binding MRNA Binding Structural Constituent Of Ribosome Protein Binding Cadherin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Negative Regulation Of RNA Splicing
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases			Diamond-Blackfan anemia (DBA)
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677) Plateletcrit ( 32888494 27863252) Red blood cell count ( 29403010)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Asthma ( 31959851 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 25644384) Hypothyroidism ( 27182965) Inflammatory skin disease ( 25574825) Lymphocyte counts ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Nonsyndromic cleft lip with cleft palate ( 28232668) Psoriasis ( 20953189 25574825) Refractive error ( 32231278) Vitiligo ( 22951725)
Interacting Genes		4 interacting genes: MDC1 MRPL38 PRIM2 TP53	7 interacting genes: APP NDRG1 OTX2 PTEN SDCBP SRPK2 TSR2
Entrez ID		5557	6231
HPRD ID		08899	04743
Ensembl ID		ENSG00000198056	ENSG00000197728
Uniprot IDs		P49642	A0A024RB14 P62854
PDB IDs		4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6G5H 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZVH 6ZVJ 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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