PRIM1 and PRIM2

Data Source:
BioGRID (two hybrid)

		PRIM1	PRIM2
Description		DNA primase subunit 1	DNA primase subunit 2
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GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane	Nucleoplasm Alpha DNA Polymerase:primase Complex
	Molecular Function	DNA Primase Activity Protein Binding Metal Ion Binding	DNA Binding Protein Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication	G1/S Transition Of Mitotic Cell Cycle DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677) Plateletcrit ( 32888494 27863252) Red blood cell count ( 29403010)	Chronotype ( 30696823) Coronary artery disease ( 33020668) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Systemic lupus erythematosus ( 28714469)
Interacting Genes		4 interacting genes: MDC1 MRPL38 PRIM2 TP53	6 interacting genes: KDM1A POLA1 POLA2 PRIM1 RECK SUV39H1
Entrez ID		5557	5558
HPRD ID		08899	08900
Ensembl ID		ENSG00000198056	ENSG00000146143
Uniprot IDs		P49642	A0A024RD43 P49643
PDB IDs		4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4	3L9Q 3Q36 4BPU 4BPW 4BPX 4RR2 5DQO 5EXR 5F0Q 5F0S 5I7M 6DHW
Enriched GO Terms of Interacting Partners?
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