PRIM1 and PDE1B

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRIM1	PDE1B
Description		DNA primase subunit 1	phosphodiesterase 1B
Image
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane	Cytosol Neuronal Cell Body
	Molecular Function	DNA Primase Activity Protein Binding Metal Ion Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-dependent Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Calmodulin Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity Calcium- And Calmodulin-regulated 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication	Regulation Of Neurotransmitter Levels Response To Amphetamine Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Locomotory Behavior Visual Learning Monocyte Differentiation Cellular Response To Macrophage Colony-stimulating Factor Stimulus Regulation Of Dopamine Metabolic Process Serotonin Metabolic Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Cam-PDE 1 activation cGMP effects G alpha (s) signalling events
Drugs			Caffeine Caffeine Nicardipine Felodipine Bepridil S,S-(2-Hydroxyethyl)Thiocysteine Trapidil
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677) Plateletcrit ( 32888494 27863252) Red blood cell count ( 29403010)	Post bronchodilator FEV1 in COPD ( 26634245)
Interacting Genes		4 interacting genes: MDC1 MRPL38 PRIM2 TP53	2 interacting genes: POT1 UBE3A
Entrez ID		5557	5153
HPRD ID		08899	01388
Ensembl ID		ENSG00000198056	ENSG00000123360
Uniprot IDs		P49642	A0A024RB59 B3KX78 B4DK72 Q01064 Q7Z364
PDB IDs		4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4	1LXR 1TAZ 4NPV 4NPW 5B25 5UOY 5UP0 5W6E
Enriched GO Terms of Interacting Partners?
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