PIP4P2 and MMP16

Data Source:
BioGRID (proximity labelling technology)

		PIP4P2	MMP16
Description		phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2	matrix metallopeptidase 16
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Late Endosome Membrane	Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Matrix
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity	Metalloendopeptidase Activity Enzyme Activator Activity Zinc Ion Binding Metalloaminopeptidase Activity
	Biological Process	Phosphatidylinositol Dephosphorylation Negative Regulation Of Phagocytosis	Skeletal System Development Endochondral Ossification Proteolysis Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Chondrocyte Proliferation Embryonic Cranial Skeleton Morphogenesis Regulation Of Catalytic Activity Craniofacial Suture Morphogenesis
Pathways			Activation of Matrix Metalloproteinases
Drugs			Marimastat Batimastat
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Body mass index and cholesterol (psychopharmacological treatment) ( 22417934) Cerebral amyloid deposition (PET imaging) ( 26252872) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Heel bone mineral density ( 30598549) Irritable mood ( 29500382) Migraine without aura ( 23793025) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 21926974 29483656 22688191 30285260 23974872) Sweet taste perception in obesity with metabolic syndrome ( 31005965)
Interacting Genes		5 interacting genes: GTF2IRD1 NEDD4L SLC10A6 TNF ZFYVE27	2 interacting genes: KISS1 LRP1
Entrez ID		55529	4325
HPRD ID		13233	03776
Ensembl ID		ENSG00000155099	ENSG00000156103
Uniprot IDs		Q8N4L2	P51512
PDB IDs			1RM8
Enriched GO Terms of Interacting Partners?
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