MACROH2A2 and H2BC15

Data Source:
BioGRID (two hybrid)

		MACROH2A2	H2BC15
Description		macroH2A.2 histone	H2B clustered histone 15
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleosome Barr Body Nucleoplasm Extracellular Exosome	Nucleosome Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity	DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Chromatin Silencing Brain Development Dosage Compensation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Establishment Of Protein Localization To Chromatin Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I	Nucleosome Assembly Protein Ubiquitination
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS
Interacting Genes		3 interacting genes: FAM133A H2BC15 WWP1	19 interacting genes: BCCIP EWSR1 FAM133A FAM9A H1-7 H2AB2 H2AB3 H2AC18 H2AC19 H2AC4 H2AC8 MACROH2A1 MACROH2A2 NKAPD1 PRR13 RPL22 SPANXN2 SREK1IP1 TSPYL2
Entrez ID		55506	8341
HPRD ID		13625	11899
Ensembl ID		ENSG00000099284	ENSG00000233822
Uniprot IDs		A0A024QZP6 Q9P0M6	A0A024RCJ9 Q99877
PDB IDs		2XD7 6FY5
Enriched GO Terms of Interacting Partners?
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