MNS1 and FCHSD2

Data Source:
BioGRID (two hybrid)

		MNS1	FCHSD2
Description		meiosis specific nuclear structural 1	FCH and double SH3 domains 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Intermediate Filament Axoneme Motile Cilium Sperm Flagellum	Plasma Membrane Clathrin-coated Pit Neuromuscular Junction Recycling Endosome Stereocilium Shaft
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Spermatogenesis Cilium Organization Positive Regulation Of Cilium Assembly Meiotic Cell Cycle Left/right Axis Specification	Neuromuscular Synaptic Transmission Protein Transport Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Clathrin-dependent Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 26956414 23770605) Clozapine-induced agranulocytosis ( 25187353) Hematology traits ( 30576415) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Albumin-globulin ratio ( 29403010) Crohn's disease ( 23850713 23266558) Endometrial cancer (endometrioid histology) ( 30093612) Health literacy ( 31250787) Nicotine dependence symptom count ( 25555482) Serum total protein level ( 29403010) Systemic lupus erythematosus ( 26663301)
Interacting Genes		24 interacting genes: CCND3 CDR2 CEP63 DISC1 EP400 EWSR1 FCHSD2 GIGYF1 IQCB1 KDM1A KIAA0753 KRT34 KRT75 PICK1 RSPH14 SNX32 STMN3 THOC7 TNNI1 TNNI2 TRIM54 TXLNB USHBP1 ZMYND12	52 interacting genes: ABCF3 ACAP1 ANKS1A ATPAF2 BORCS6 C2orf73 C9orf78 CASK CCDC120 CCDC158 CCDC183 CCDC85B CCT2 CFAP36 CHKA CTAG1A CTAG1B DAPP1 ENKD1 FAM9B GPRASP2 HDAC4 HGS HOMER1 HSP90AB1 HSPA5 HTRA1 ITSN1 ITSN2 KIFC3 LCA5L LDOC1 MNS1 MRFAP1 MSL1 MTUS2 PDE4DIP PRKAR1B RINT1 SASS6 SERTAD3 SH2D4A SH3BGR SRP72 TLE5 TSGA10IP USHBP1 VCPIP1 VPS37C WAS WASL ZNF587
Entrez ID		55329	9873
HPRD ID		10967	13321
Ensembl ID		ENSG00000138587	ENSG00000137478
Uniprot IDs		B3KQ70 Q8NEH6	O94868
PDB IDs			2DL5 2DL7 6GBU
Enriched GO Terms of Interacting Partners?
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