FCHSD2 and ACAP1

Data Source:
BioGRID (two hybrid)

		FCHSD2	ACAP1
Description		FCH and double SH3 domains 2	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
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GO Annotations	Cellular Component	Plasma Membrane Clathrin-coated Pit Neuromuscular Junction Recycling Endosome Stereocilium Shaft	Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Neuromuscular Synaptic Transmission Protein Transport Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Clathrin-dependent Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Protein Transport Positive Regulation Of GTPase Activity
Pathways
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Crohn's disease ( 23850713 23266558) Endometrial cancer (endometrioid histology) ( 30093612) Health literacy ( 31250787) Nicotine dependence symptom count ( 25555482) Serum total protein level ( 29403010) Systemic lupus erythematosus ( 26663301)	Autoimmune thyroid disease ( 32581359) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 33536424) White blood cell count ( 32888494)
Interacting Genes		52 interacting genes: ABCF3 ACAP1 ANKS1A ATPAF2 BORCS6 C2orf73 C9orf78 CASK CCDC120 CCDC158 CCDC183 CCDC85B CCT2 CFAP36 CHKA CTAG1A CTAG1B DAPP1 ENKD1 FAM9B GPRASP2 HDAC4 HGS HOMER1 HSP90AB1 HSPA5 HTRA1 ITSN1 ITSN2 KIFC3 LCA5L LDOC1 MNS1 MRFAP1 MSL1 MTUS2 PDE4DIP PRKAR1B RINT1 SASS6 SERTAD3 SH2D4A SH3BGR SRP72 TLE5 TSGA10IP USHBP1 VCPIP1 VPS37C WAS WASL ZNF587	11 interacting genes: AKT1 FCHSD2 GRB2 IFFO1 ITGB1 NEBL RABGAP1L SH3RF1 TFRC UQCRB VAMP3
Entrez ID		9873	9744
HPRD ID		13321	08474
Ensembl ID		ENSG00000137478	ENSG00000072818
Uniprot IDs		O94868	Q15027
PDB IDs		2DL5 2DL7 6GBU	3JUE 3T9K 4CKG 4CKH 4F1P 4NSW 5H3D
Enriched GO Terms of Interacting Partners?
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