PPP2R5B and MARK2

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PPP2R5B	MARK2
Description		protein phosphatase 2 regulatory subunit B'beta	microtubule affinity regulating kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol	Nucleoplasm Cytoplasm Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Microtubule Bundle
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Cadherin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Dephosphorylation Regulation Of Signaling Receptor Activity Positive Regulation Of Neuron Projection Development Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Autophosphorylation IRE1-mediated Unfolded Protein Response Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of G0 To G1 Transition Positive Regulation Of Cell Cycle Arrest Cellular Response To Growth Factor Stimulus	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Microtubule Binding
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion XBP1(S) activates chaperone genes CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Serum uric acid levels ( 32514006)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)
Interacting Genes		7 interacting genes: AXIN1 CHEK2 IER3 MAPK1 PPP2CA PPP2R1A SGO1	32 interacting genes: BAIAP2 CAMK1 CASK DVL3 FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MAPT MTCL1 NEDD4 NEDD4L PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 STK4 UTRN YWHAB YWHAQ YWHAZ
Entrez ID		5526	2011
HPRD ID		09038	02753
Ensembl ID		ENSG00000068971	ENSG00000072518
Uniprot IDs		A0A024R593 Q15173	A0A140VJP1 A8K2S4 Q7KZI7
PDB IDs			3IEC 5EAK 5KZ7 5KZ8
Enriched GO Terms of Interacting Partners?
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