ARHGEF10L and DRAP1

Data Source:
HPRD (two hybrid)

		ARHGEF10L	DRAP1
Description		Rho guanine nucleotide exchange factor 10 like	DR1 associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Negative Cofactor 2 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	GTPase Activator Activity	Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Actin Cytoskeleton Organization SREBP Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of Stress Fiber Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Signaling by NODAL Signaling by Activin
Drugs
Diseases
GWAS		Basal cell carcinoma ( 18849993) Initial pursuit acceleration in psychotic disorders ( 29064472) Insomnia ( 27992416) Obesity-related traits ( 23251661) Response to hepatitis C treatment ( 22095909)	Acne (severe) ( 24927181) Asthma ( 31959851) Eosinophil percentage of granulocytes ( 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		4 interacting genes: ANXA9 DRAP1 NR4A1 SCN2A	31 interacting genes: APP ARHGEF10L CDKN2C DNAJB11 DR1 FBXO7 FEZ1 FEZ2 FOXH1 GTF2B LMO2 LNX1 LNX2 MCRS1 MORF4L1 NCK2 NFYB PICK1 PIK3R3 PLEKHF2 POLE3 RPL9 SDCBP SRPK2 TAF9 TAF9B TBP TK1 TNFRSF14 TTF2 ZEB1
Entrez ID		55160	10589
HPRD ID		07679	03796
Ensembl ID		ENSG00000074964	ENSG00000175550
Uniprot IDs		B4DTL3 Q5VXI4 Q9HCE6	Q14919
PDB IDs			1JFI
Enriched GO Terms of Interacting Partners?
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