DRAP1 and ZEB1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		DRAP1	ZEB1
Description		DR1 associated protein 1	zinc finger E-box binding homeobox 1
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GO Annotations	Cellular Component	Nucleus Negative Cofactor 2 Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Identical Protein Binding Protein Heterodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding E-box Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nervous System Development Cytokine-mediated Signaling Pathway Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Anatomical Structure Development
Pathways		Signaling by NODAL Signaling by Activin	Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases			Posterior polymorphous corneal dystrophy (PPCD) Fuchs corneal dystrophy (FECD); Fuchs endothelial corneal dystrophy
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Eosinophil percentage of granulocytes ( 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Severe influenza A (H1N1) infection ( 26379185)	Pulse pressure ( 28135244) Uterine fibroids ( 31649266) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		31 interacting genes: APP ARHGEF10L CDKN2C DNAJB11 DR1 FBXO7 FEZ1 FEZ2 FOXH1 GTF2B LMO2 LNX1 LNX2 MCRS1 MORF4L1 NCK2 NFYB PICK1 PIK3R3 PLEKHF2 POLE3 RPL9 SDCBP SRPK2 TAF9 TAF9B TBP TK1 TNFRSF14 TTF2 ZEB1	11 interacting genes: ATM CDK6 CTBP1 CTBP2 DRAP1 EP300 KAT5 SMAD2 SMAD3 SMAD7 USP51
Entrez ID		10589	6935
HPRD ID		03796	01798
Ensembl ID		ENSG00000175550	ENSG00000148516
Uniprot IDs		Q14919	B2RBI8 B4DGU2 P37275
PDB IDs		1JFI	2E19
Enriched GO Terms of Interacting Partners?
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