PID1 and CPSF7

Data Source:
BioGRID (two hybrid)

		PID1	CPSF7
Description		phosphotyrosine interaction domain containing 1	cleavage and polyadenylation specific factor 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Membrane
	Molecular Function	Protein Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Energy Reserve Metabolic Process Positive Regulation Of Gene Expression Regulation Of Mitochondrial Fusion Cellular Response To Leptin Stimulus Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Fat Cell Proliferation Mitochondrion Morphogenesis Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Fatty Acid Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of ATP Biosynthetic Process Positive Regulation Of ATP Biosynthetic Process	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing Protein Tetramerization Protein Heterotetramerization Pre-mRNA Cleavage Required For Polyadenylation MRNA Alternative Polyadenylation Messenger Ribonucleoprotein Complex Assembly
Pathways			mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561) Coronary artery disease ( 33020668) FEV1 ( 30804560) HDL cholesterol levels ( 32203549) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (antimigraine preparations) ( 31015401) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Total cholesterol levels ( 30498476) Triglyceride levels ( 32203549) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432)
Interacting Genes		15 interacting genes: ADAMTSL4 BANP CBY2 CCDC33 CPSF7 CRX DNAAF6 GOLGA2 GOPC KRTAP10-1 LRP1 MDFI NME1 NOTCH2NLA THAP1	59 interacting genes: APBB1 ARMC7 ATXN1 CATSPER1 CFAP206 CLK2 CSNK2A1 DVL2 EPM2AIP1 EWSR1 GAS8 GCC1 GRB2 GUCD1 HINT1 HNRNPF ITCH LENG8 LNX1 MIR1-1 MIR1-2 MIR10B MIR128-2 MIR141 MIR155 MIR16-1 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR25 MIR29C MIR34B MIR7-1 MIR9-2 MIR93 MIRLET7B NCK2 NUDT21 PATZ1 PID1 PRKAA2 PRMT2 RBM10 RUNX1T1 SEC23B SMAD3 SNRNP25 SNX18 SORBS3 SPG21 SRPK2 SUMO2 TLE5 TNS2 U2AF2 WBP4 WWOX
Entrez ID		55022	79869
HPRD ID		07944	16906
Ensembl ID		ENSG00000153823	ENSG00000149532
Uniprot IDs		Q7Z2X4	B4DGF8 Q8N684
PDB IDs			3N9U
Enriched GO Terms of Interacting Partners?
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