LAMTOR1 and ABCF3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LAMTOR1	ABCF3
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	ATP binding cassette subfamily F member 3
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Late Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Membrane Raft Extracellular Exosome Ragulator Complex Ficolin-1-rich Granule Membrane	Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Binding Molecular Adaptor Activity	Protein Binding ATP Binding ATPase Activity Cadherin Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Receptor Recycling Endosome Organization Lysosome Organization Cell Cycle Arrest Regulation Of Cholesterol Esterification Regulation Of Cholesterol Efflux Endosomal Transport Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Lysosome Localization Cellular Protein Localization Cholesterol Homeostasis Neutrophil Degranulation Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Regulation Of Cholesterol Import Cellular Response To Amino Acid Stimulus	Defense Response To Virus
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Major depressive disorder ( 22472876) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: ABCF3 CAPN1 CCDC90B CTAG1A CTAG1B EEF1A1 TRIM14	20 interacting genes: ACIN1 CCDC33 DLEU1 DNALI1 FBXO7 FCHSD2 HIRIP3 LAMTOR1 MDFI MOCS2 NOA1 PSME3 RBPMS SLC35E1 SPP1 TBPL1 THAP1 TOE1 TRIM14 TRIM27
Entrez ID		55004	55324
HPRD ID		07933	12404
Ensembl ID		ENSG00000149357	ENSG00000161204
Uniprot IDs		Q6IAA8	A0A0S2Z5L1 Q9NUQ8
PDB IDs		5X6U 5X6V 5Y39 5Y3A 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
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