PPL and PKD1

Data Source:
BioGRID (two hybrid)

		PPL	PKD1
Description		periplakin	polycystin 1, transient receptor potential channel interacting
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GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome	Golgi Membrane Polycystin Complex Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Cation Channel Complex Calcium Channel Complex Ciliary Membrane Extracellular Exosome
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt-activated Receptor Activity Ion Channel Binding
	Biological Process	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification	Cartilage Condensation In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Cell Cycle Arrest Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Wnt Signaling Pathway Peptidyl-serine Phosphorylation Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Response To Fluid Shear Stress Lymph Vessel Morphogenesis Cytoplasmic Sequestering Of Transcription Factor Skin Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Signaling By Wnt Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases			Polycystic kidney disease
GWAS		Adult body size ( 32376654) Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)	Appendicular lean mass ( 33097823) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418)
Interacting Genes		43 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16	30 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 SIAH1 SRC TLN1 VCL VIM
Entrez ID		5493	5310
HPRD ID		04187	03203
Ensembl ID		ENSG00000118898	ENSG00000008710
Uniprot IDs		O60437	P98161
PDB IDs		4Q28	1B4R 6A70
Enriched GO Terms of Interacting Partners?
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