NSD3 and ETV3

Data Source:
BioGRID (two hybrid)

		NSD3	ETV3
Description		nuclear receptor binding SET domain protein 3	ETS variant transcription factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Repressor Complex
	Molecular Function	Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific) Transcription Regulator Activator Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DEAD/H-box RNA Helicase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K36 Trimethylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Biological_process Negative Regulation Of Cell Population Proliferation Cell Differentiation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Interacting Genes		42 interacting genes: AKT1 ATM BCAR3 CASP8 CBLC CBX3 CBX5 CDKN2A CHEK2 DAXX DOCK7 ESR1 ETV3 FGFR4 GLIS2 GLYR1 H1-1 H3-5 H3C1 H4C1 HOXC4 MLLT6 MNDA MYC NFIC PAX2 PPM1D RB1CC1 SEPTIN6 SLU7 SOX3 SOX4 SPAG8 STAC3 TCF3 TEAD2 TERT TGFB1 TRIM55 TRIM63 UBE2I ZNF557	3 interacting genes: APP DDX20 NSD3
Entrez ID		54904	2117
HPRD ID		06155	01282
Ensembl ID		ENSG00000147548	ENSG00000117036
Uniprot IDs		Q9BZ95	P41162
PDB IDs		2DAQ 2NCZ 2ND1 4GND 4GNE 4GNF 4GNG 4RXJ 5UPD 6CEN 6G24 6G25 6G27 6G29 6G2B 6G2C 6G2E 6G2F 6G2O 6G3P 6G3T 7CRP 7CRQ 7CRR
Enriched GO Terms of Interacting Partners?
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