BORCS6 and EPS8

Data Source:
BioGRID (two hybrid)

		BORCS6	EPS8
Description		BLOC-1 related complex subunit 6	epidermal growth factor receptor pathway substrate 8
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane BORC Complex	Plasma Membrane Cell Cortex Growth Cone Vesicle Stereocilium Ruffle Membrane Synapse Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Actin Binding Protein Binding Small GTPase Binding Signaling Adaptor Activity
	Biological Process	Lysosome Localization	Rho Protein Signal Transduction Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Regulation Of Catalytic Activity Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Positive Regulation Of Ruffle Assembly
Pathways
Drugs
Diseases
GWAS			Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)
Interacting Genes		38 interacting genes: ABI2 BEX2 C19orf25 C1orf109 C1orf216 CCHCR1 DCTN2 DISC1 EPS8 EXOC8 EXOSC5 FAM161B FAM9C FBXO44 FCHSD2 GAS8 HAUS1 HGS INSYN1 KANK2 KXD1 LAMTOR2 LNX1 MED21 MOS NDEL1 NTAQ1 OSTF1 PKNOX1 PLA2G4A RCOR3 RIBC1 SHPRH SPG21 TACC2 USHBP1 VPS52 ZNF655	61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3
Entrez ID		54785	2059
HPRD ID		13368	02563
Ensembl ID		ENSG00000196544	ENSG00000151491
Uniprot IDs		Q96GS4	B4E3T6 Q12929
PDB IDs			2E8M
Enriched GO Terms of Interacting Partners?
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