OTUD4 and ALKBH3

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		OTUD4	ALKBH3
Description		OTU deubiquitinase 4	alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm Mitochondrion Cytosol
	Molecular Function	RNA Binding Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Molecular Adaptor Activity Lys63-specific Deubiquitinase Activity	Protein Binding Ferrous Iron Binding L-ascorbic Acid Binding DNA-N1-methyladenine Dioxygenase Activity RNA N1-methyladenosine Dioxygenase Activity
	Biological Process	Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Toll-like Receptor Signaling Pathway Innate Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of DNA Demethylation Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of Interleukin-1-mediated Signaling Pathway	DNA Repair DNA Dealkylation Involved In DNA Repair Cell Population Proliferation Oxidative Single-stranded DNA Demethylation Oxidative Single-stranded RNA Demethylation
Pathways			ALKBH3 mediated reversal of alkylation damage
Drugs			Ascorbic acid
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412) Lung function (FEV1) ( 30061609) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 31628463) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252) Subcortical volume (MOSTest) ( 32665545)	Chronotype ( 30696823) Morning person ( 30696823)
Interacting Genes		10 interacting genes: ALKBH3 EXOSC8 MAVS REL STAT1 TCF4 UBC USP7 VDR ZNF655	12 interacting genes: AK8 FBXO7 GLRX3 GOLGA2 IKZF1 LNX1 OTUD4 SRPK1 SRPK2 TRIM55 TRIM63 ZDHHC17
Entrez ID		54726	221120
HPRD ID		11033	16793
Ensembl ID		ENSG00000164164	ENSG00000166199
Uniprot IDs		Q01804	Q96Q83
PDB IDs			2IUW
Enriched GO Terms of Interacting Partners?
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