RNF186 and SESN2

Data Source:
BioGRID (pull down)

		RNF186	SESN2
Description		ring finger protein 186	sestrin 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleus Cytoplasm Mitochondrion Cytosol Nucleotide-activated Protein Kinase Complex TORC2 Complex GATOR2 Complex Atg1/ULK1 Kinase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	GDP-dissociation Inhibitor Activity Protein Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Sulfiredoxin Activity Leucine Binding
	Biological Process	Protein K29-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K63-linked Ubiquitination Protein Localization To Mitochondrion	Regulation Of Protein Phosphorylation Regulation Of Gluconeogenesis Fatty Acid Beta-oxidation Response To Glucose Positive Regulation Of Macroautophagy Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Mitochondrial DNA Metabolic Process Response To Insulin Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Response To Glucose Starvation Glucose Homeostasis Protein Kinase B Signaling Glucose Import Triglyceride Homeostasis Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Positive Regulation Of Protein Localization To Nucleus Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Negative Regulation Of TORC1 Signaling Positive Regulation Of Lipophagy Cellular Response To Leucine Starvation Regulation Of CAMP-dependent Protein Kinase Activity
Pathways			TP53 Regulates Metabolic Genes Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908 20228799 19122664 23511034)	Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		6 interacting genes: HIVEP1 PBX3 SCAND1 SESN2 UBE2D2 UBE2H	3 interacting genes: MDM2 PRDX1 RNF186
Entrez ID		54546	83667
HPRD ID		07885	06378
Ensembl ID		ENSG00000178828	ENSG00000130766
Uniprot IDs		Q9NXI6	P58004
PDB IDs			5CUF 5DJ4 5T0N 6N0M
Enriched GO Terms of Interacting Partners?
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