FAM193B and PKN2

Data Source:
BioGRID (two hybrid)

		FAM193B	PKN2
Description		family with sequence similarity 193 member B	protein kinase N2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Nuclear Body Lamellipodium Midbody Cleavage Furrow Protein-containing Complex Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Histone Deacetylase Binding Cadherin Binding RNA Polymerase Binding
	Biological Process		Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epithelial Cell Migration Viral Process Peptidyl-serine Phosphorylation Cell Projection Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Cell Motility
Pathways			RHO GTPases activate PKNs
Drugs			Fostamatinib
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 25282103 31562340) Intraocular pressure ( 29617998) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Narcolepsy ( 23459209) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Periodontal microbiota ( 22699663) Photic sneeze reflex ( 27182965) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Rosacea symptom severity ( 29771307) Serum protein levels (sST2) ( 23999434) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Systolic blood pressure ( 30224653 27841878) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		12 interacting genes: ATXN1 CDC25A CNOT11 GOLGA2 GSK3A GSK3B LDOC1 MAPK8 PKN2 SPANXN2 TRIM23 TRIM27	18 interacting genes: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTPN13 RHOA SUMO2
Entrez ID		54540	5586
HPRD ID		07671	03972
Ensembl ID		ENSG00000146067	ENSG00000065243
Uniprot IDs		Q6IPW0 Q96PV7	Q16513
PDB IDs			4CRS 4RRV 6CCY 6GBE
Enriched GO Terms of Interacting Partners?
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