POU3F2 and SOX11

Data Source:
HPRD (in vitro)

		POU3F2	SOX11
Description		POU class 3 homeobox 2	SRY-box transcription factor 11
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Epidermis Development Negative Regulation Of Gene Expression Astrocyte Development Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Hypothalamus Cell Differentiation Neurohypophysis Development Myelination In Peripheral Nervous System Neuron Differentiation Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Neuron Development Regulation Of Axonogenesis Cellular Response To Organic Substance	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Kidney Development Neural Tube Formation Lens Morphogenesis In Camera-type Eye Outflow Tract Morphogenesis Cardiac Ventricle Formation Noradrenergic Neuron Differentiation Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Glial Cell Proliferation Neural Crest Cell Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Spinal Cord Development Glial Cell Development Cell Differentiation Neuron Differentiation Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Hippo Signaling Skeletal Muscle Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Secretion Sympathetic Nervous System Development Embryonic Digestive Tract Morphogenesis Embryonic Skeletal System Morphogenesis Negative Regulation Of Lymphocyte Proliferation Positive Regulation Of Neurogenesis Hard Palate Development Soft Palate Development Limb Bud Formation Negative Regulation Of Glial Cell Proliferation Ventricular Septum Morphogenesis Lung Morphogenesis Negative Regulation Of Cell Death Neuroepithelial Cell Differentiation Eyelid Development In Camera-type Eye Somite Development Cornea Development In Camera-type Eye Closure Of Optic Fissure Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Lens Epithelial Cell Proliferation
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Bipolar disorder ( 24618891 27329760) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Chronotype ( 30696823) Educational attainment ( 25201988) Erectile dysfunction ( 30583798) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) Intelligence ( 28530673) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) QT interval (drug interaction) ( 23459443) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Automobile speeding propensity ( 30643258) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronic kidney disease ( 20383146) Crohn's disease ( 23266558) Diabetic kidney disease ( 26305897) Hip circumference ( 25673412) Intraocular pressure ( 29617998) Obesity in adult survivors of childhood cancer exposed to cranial radiation ( 25963547) Obesity-related traits ( 23251661) Proteinuria and chronic kidney disease ( 26420894) Tuberculosis ( 24057671) Type 2 diabetes ( 31118516)
Interacting Genes		11 interacting genes: EP300 GTF2B NFYA NFYB NFYC PAX3 POU3F4 PQBP1 SOX10 SOX11 TBP	3 interacting genes: MTNR1A POU3F2 POU3F3
Entrez ID		5454	6664
HPRD ID		02734	02940
Ensembl ID		ENSG00000184486	ENSG00000176887
Uniprot IDs		P20265	P35716
PDB IDs			6T78 6T7A 6T7C 6T7D
Enriched GO Terms of Interacting Partners?
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