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ADAMTSL4 and HGF
Data Source:
BioGRID
(two hybrid)
ADAMTSL4
HGF
Description
ADAMTS like 4
hepatocyte growth factor
Image
No pdb structure
GO Annotations
Cellular Component
Interstitial Matrix
Endoplasmic Reticulum Lumen
Extracellular Matrix
Collagen-containing Extracellular Matrix
Extracellular Region
Extracellular Space
Membrane
Platelet Alpha Granule Lumen
Molecular Function
Protease Binding
Metalloendopeptidase Activity
Protein Binding
Serine-type Endopeptidase Activity
Protein Binding
Growth Factor Activity
Chemoattractant Activity
Identical Protein Binding
Protein-containing Complex Binding
Biological Process
Epithelial Cell Development
Proteolysis
Apoptotic Process
Extracellular Matrix Organization
Positive Regulation Of Apoptotic Process
MAPK Cascade
Activation Of MAPK Activity
Mitotic Cell Cycle
Cell Morphogenesis
Epithelial To Mesenchymal Transition
Liver Development
Positive Regulation Of Protein Phosphorylation
Platelet Degranulation
Proteolysis
Negative Regulation Of Autophagy
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Cytokine-mediated Signaling Pathway
Hyaluronan Metabolic Process
Positive Regulation Of Cell Migration
Animal Organ Regeneration
Positive Regulation Of Myelination
Negative Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-10 Production
Negative Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Hepatocyte Growth Factor Stimulus
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Growth Factor Receptor Signaling Pathway
Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Chemotaxis
Myoblast Proliferation
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling
Positive Regulation Of Neuron Projection Regeneration
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of P38MAPK Cascade
Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Tau-protein Kinase Activity
Positive Regulation Of DNA Biosynthetic Process
Pathways
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
Platelet degranulation
PIP3 activates AKT signaling
Interleukin-7 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
Drugs
Heparin
O2-Sulfo-Glucuronic Acid
N,O6-Disulfo-Glucosamine
ABT-510
Foretinib
Diseases
Ectopia lentis
GWAS
Asthma (
32296059
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Coronary artery disease (
29212778
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Migraine (
27322543
)
Refractive error (
32231278
)
Rhegmatogenous retinal detachment (
23585552
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Blood protein levels (
30072576
29875488
)
Endothelial growth factor levels (
25552591
)
Gestational age at birth (maternal effect) (
28598419
)
Gout (
22179738
)
Gout (normal type) (
32238385
)
Hepatocyte growth factor levels (
27989323
25998175
)
Intraocular pressure (
29785010
29235454
)
Rosacea symptom severity (
29771307
)
Spontaneous preterm birth (maternal effect) (
28598419
)
Transverse temporal cortex volume (
31530798
)
Tuberculosis (
29036319
)
Interacting Genes
209 interacting genes:
ADAM12
ADAMTSL5
ALPP
AMMECR1
APOL6
AQP1
ARNT2
ASPSCR1
ATG9A
BAG4
BANF2
BOLA2
BOLA2B
BRME1
CATSPER1
CBX3
CCDC26
CFAP206
CHCHD2
CHERP
CHIC2
CHRD
CHRNG
CLEC18A
COL8A1
CPNE7
CREB5
CST2
CTSB
CXCL16
CYP2S1
CYSRT1
DGCR6
DGCR6L
DIP2A
DLK2
DNPEP
DSCR8
EFEMP2
EIF4E2
EPDR1
ERCC3
EXOSC5
FAH
FAM124B
FARS2
FBLN1
FBXO17
FBXW5
FHL3
FKBP1B
FLNA
FRS3
GATA2
GIP
GLRX3
GLYCTK
GMCL2
GNE
GNG13
GNMT
GOLGA8EP
GSTP1
GUCD1
HEXIM2
HGF
HNRNPLL
HOXA1
HOXC8
HSD3B7
INS
IP6K1
ITGB2
ITGB4
JOSD1
KCTD7
KCTD9
KIF1A
KLHL38
KRTAP1-1
KRTAP1-5
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-3
KRTAP19-2
KRTAP21-2
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP5-2
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-7
KRTAP5-9
KRTAP6-2
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-4
LCE1A
LCE1B
LCE1C
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LCE4A
LGALS14
LHX4
LINC00671
LMO1
LMO2
LMO4
LNX1
LONRF1
LRFN4
LRRC29
MAGOHB
MAPKBP1
MGAT5B
MID2
MKRN3
MORN3
MVP
MYLIP
MYO15B
NATD1
NBPF19
NEK8
NFKBID
NMUR2
NOTCH2NLA
NR4A3
NTAQ1
NTF4
NTN4
NUFIP2
OLFM3
OTX1
PCSK5
PID1
PIN1
PKN1
PLSCR1
PLSCR4
POLD1
POLR1C
POU4F2
PRKAB2
PRR19
PTGER3
PTPMT1
QPRT
R3HDM2
RAB2B
RCHY1
RGL2
RHOJ
RPS19BP1
RUNX1T1
SALL2
SCNM1
SHFL
SLC13A5
SLC23A1
SLC6A20
SLIT1
SMARCC1
SORBS3
SPATA8
SPINK2
SPRY1
SPRY2
STK16
SUSD6
TAPBPL
TCEA2
TFAP2D
TGFB1
THAP6
TMEM150A
TMSB4XP6
TOP3B
TRIM42
TRIM55
TRIM63
TRIP6
TSSK3
TUBGCP4
USP21
VASN
VENTX
VWC2
ZFHX2
ZNF330
ZNF414
ZNF417
ZNF587
37 interacting genes:
ADAMTSL4
ARNT
BRCA1
CCND2
CDK4
CDK6
CDKN2A
CDKN2B
CLEC3B
EPHA2
ERBB2
F11
FGFR4
FN1
GLIS2
HGFAC
HPN
KLKB1
LATS2
LCN2
MAP2K5
MAP2K6
MDM4
MEOX2
MET
MYC
NF2
PDGFRA
PLAU
RAF1
SDC1
SDC2
ST14
STK11
TEAD2
VTN
YWHAG
Entrez ID
54507
3082
HPRD ID
18237
00799
Ensembl ID
ENSG00000143382
ENSG00000019991
Uniprot IDs
A0A669KBE7
B7ZMJ3
Q6UY14
Q9UFG7
P14210
PDB IDs
1BHT
1GMN
1GMO
1GP9
1NK1
1SHY
1SI5
2HGF
2QJ2
3HMS
3HMT
3HN4
3MKP
3SP8
4D3C
4K3J
4O3T
4O3U
5COE
5CP9
5CS1
5CS3
5CS5
5CS9
5CSQ
5CT1
5CT2
5CT3
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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