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POLR2C and SMARCC2
Data Source:
HPRD
(two hybrid)
POLR2C
SMARCC2
Description
RNA polymerase II subunit C
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Cytosol
Chromatin
Nucleoplasm
SWI/SNF Complex
Protein-containing Complex
NpBAF Complex
NBAF Complex
Molecular Function
DNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Protein Dimerization Activity
Transcription Coactivator Activity
Protein Binding
Nucleosomal DNA Binding
Histone Binding
Biological Process
MRNA Splicing, Via Spliceosome
Transcription-coupled Nucleotide-excision Repair
Transcription, DNA-templated
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Fibroblast Growth Factor Receptor Signaling Pathway
RNA Metabolic Process
Somatic Stem Cell Population Maintenance
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Viral Transcription
Regulation Of Gene Silencing By MiRNA
Nucleosome Disassembly
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Nervous System Development
ATP-dependent Chromatin Remodeling
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
RMTs methylate histone arginines
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS
Asthma (
31619474
)
Refractive error (
32231278
)
Interacting Genes
29 interacting genes:
ATF4
ATF7IP
C11orf58
CCHCR1
EEF1A1
ERG28
ITCH
LRIF1
MYOG
NECAB2
NEDD4
NFKBIA
NUDT21
OTUD5
POLR2A
POLR2B
POLR2D
POLR2E
POLR2F
POLR2G
POLR2H
POLR2J
POLR2K
POLR2L
SMARCC2
STC2
TAF15
UBC
UBE2W
26 interacting genes:
ARRB2
ATXN1
ATXN1L
BAZ1B
CSNK2A1
EWSR1
FUS
GATA1
IFTAP
ITCH
ITSN1
KLF1
KRT27
MCPH1
NOVA1
PEX14
PHYHIP
POLR2C
RAB1B
RELB
SMARCB1
SP1
SRGAP3
TAF15
TERF1
TERF2IP
Entrez ID
5432
6601
HPRD ID
15945
03437
Ensembl ID
ENSG00000102978
ENSG00000139613
Uniprot IDs
P19387
Q6FGR6
A0A024RB22
F8VXC8
Q8TAQ2
PDB IDs
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
6KAG
6LTH
6LTJ
Enriched GO Terms of Interacting Partners
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