ERRFI1 and RB1CC1

Data Source:
BioGRID (two hybrid)

		ERRFI1	RB1CC1
Description		ERBB receptor feedback inhibitor 1	RB1 inducible coiled-coil 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Phagophore Assembly Site Autophagosome Membrane Lysosome Endoplasmic Reticulum Membrane Cytosol Extrinsic Component Of Membrane Nuclear Membrane Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Small GTPase Binding	Protein Binding Protein Kinase Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Interleukin-1 Beta Production Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of GTPase Activity Skin Morphogenesis Regulation Of Keratinocyte Differentiation Lung Alveolus Development Lung Vasculature Development Lung Epithelium Development Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Autophagosome Assembly Autophagy Of Mitochondrion Liver Development Positive Regulation Of Protein Phosphorylation Autophagy Cell Cycle Heart Development Macroautophagy Regulation Of Macroautophagy Autophagy Of Peroxisome Piecemeal Microautophagy Of The Nucleus Positive Regulation Of Cell Size Positive Regulation Of JNK Cascade Reticulophagy Glycophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Macroautophagy
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Hair shape ( 29220522) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Morning person ( 30696823) Response to antidepressants and depression ( 27622933) Strep throat ( 28928442) Ulcerative colitis ( 28067908)	Body size at age 10 ( 32376654) Immunoglobulin light chain (AL) amyloidosis (liver involvement) ( 28679651) Mitochondrial DNA copy number (white blood cells) ( 30704525) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		60 interacting genes: ACBD3 ADAM5 AGPAT4-IT1 AOX1 ARRDC5 ATM AURKA BAG4 BCAR3 CASP8 CDC42 CIAO2B COPS5 CRHBP DCTN6 EFEMP1 EGFR ERBB2 FGFR2 FGFR4 FYN GAS1 GNPDA2 GRB2 GTF2H2 HYDIN IL2RG MFSD5 MMP26 NEDD4 NEU1 NPC2 OSTF1 PALB2 PAPSS1 PCCA PCNA PDCD2 PHYHIPL PLEKHA3 PPIA PPM1D PSMA7 PSMB6 RAB18 RB1CC1 RUBCNL SH3YL1 SLC7A13 SMIM30 SRC TC2N TIMP4 TM2D3 TMEM165 TMEM59 WDR61 WEE1 YWHAB ZPBP	33 interacting genes: AZI2 BAP1 BLID COP1 EPSTI1 ERRFI1 EXOC1 GABARAP GABARAPL1 GABARAPL2 GLCE GREB1 HBP1 IL13RA2 IL24 ITIH5 LYPD3 MADD MRC2 NSD3 PSMC3IP PTK2 PTK2B RNF20 SYN1 TAX1BP1 TBKBP1 THRSP UBC UMPS VHL VPS45 WIF1
Entrez ID		54206	9821
HPRD ID		09218	06019
Ensembl ID		ENSG00000116285	ENSG00000023287
Uniprot IDs		B3KTV8 I6S2Y9 Q9UJM3	Q8TDY2
PDB IDs		2RF9 2RFD 2RFE 4I21 4R3P 4R3R 4ZJV	6DCE 6GMA
Enriched GO Terms of Interacting Partners?
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