ERRFI1 and CRHBP

Data Source:
BioGRID (two hybrid)

		ERRFI1	CRHBP
Description		ERBB receptor feedback inhibitor 1	corticotropin releasing hormone binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Extracellular Region Extracellular Space Nucleus Secondary Lysosome Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Microtubule Secretory Granule Dendrite Dense Core Granule Varicosity Perikaryon Axon Terminus
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Small GTPase Binding	Protein Binding Peptide Binding Corticotropin-releasing Hormone Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Interleukin-1 Beta Production Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of GTPase Activity Skin Morphogenesis Regulation Of Keratinocyte Differentiation Lung Alveolus Development Lung Vasculature Development Lung Epithelium Development Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Synaptic Transmission, Dopaminergic Inflammatory Response Signal Transduction Female Pregnancy Learning Or Memory Hormone-mediated Signaling Pathway Cellular Response To Drug Cellular Response To Potassium Ion Regulated Exocytosis Behavioral Response To Ethanol Regulation Of Corticotropin Secretion Negative Regulation Of Corticotropin Secretion Cellular Response To Calcium Ion Cellular Response To Cocaine Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Regulation Of Cellular Response To Stress Cellular Response To Gonadotropin-releasing Hormone Negative Regulation Of Corticotropin-releasing Hormone Receptor Activity Regulation Of NMDA Receptor Activity
Pathways			Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Hair shape ( 29220522) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Morning person ( 30696823) Response to antidepressants and depression ( 27622933) Strep throat ( 28928442) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576 29875488) Chronotype ( 30696823) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)
Interacting Genes		60 interacting genes: ACBD3 ADAM5 AGPAT4-IT1 AOX1 ARRDC5 ATM AURKA BAG4 BCAR3 CASP8 CDC42 CIAO2B COPS5 CRHBP DCTN6 EFEMP1 EGFR ERBB2 FGFR2 FGFR4 FYN GAS1 GNPDA2 GRB2 GTF2H2 HYDIN IL2RG MFSD5 MMP26 NEDD4 NEU1 NPC2 OSTF1 PALB2 PAPSS1 PCCA PCNA PDCD2 PHYHIPL PLEKHA3 PPIA PPM1D PSMA7 PSMB6 RAB18 RB1CC1 RUBCNL SH3YL1 SLC7A13 SMIM30 SRC TC2N TIMP4 TM2D3 TMEM165 TMEM59 WDR61 WEE1 YWHAB ZPBP	2 interacting genes: ERRFI1 UCN
Entrez ID		54206	1393
HPRD ID		09218	08348
Ensembl ID		ENSG00000116285	ENSG00000145708
Uniprot IDs		B3KTV8 I6S2Y9 Q9UJM3	P24387
PDB IDs		2RF9 2RFD 2RFE 4I21 4R3P 4R3R 4ZJV
Enriched GO Terms of Interacting Partners?
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