ACP5 and GPC4

Data Source:
HPRD (in vivo)

		ACP5	GPC4
Description		acid phosphatase 5, tartrate resistant	glypican 4
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Cytosol Integral Component Of Membrane	Nucleus Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Lysosomal Lumen Synapse Collagen-containing Extracellular Matrix Extracellular Exosome Glutamatergic Synapse Anchored Component Of Presynaptic Membrane
	Molecular Function	Acid Phosphatase Activity Ferrous Iron Binding Ferric Iron Binding	Protein Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Ossification Riboflavin Metabolic Process Dephosphorylation Bone Resorption	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Regulation Of Signal Transduction Wnt Signaling Pathway Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synaptic Membrane Adhesion Regulation Of Protein Localization To Membrane Regulation Of Presynapse Assembly
Pathways		Vitamin B2 (riboflavin) metabolism	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Multiple sclerosis (severity) ( 19010793)
Interacting Genes		11 interacting genes: EGR2 GPC4 MAPK9 PDCD5 PPP2CB RPA2 SLC35F6 SNRNP40 SPP1 TNFSF10 ZBTB16	10 interacting genes: ABHD17A ACP5 AKAP9 CCNC COL18A1 FGF2 PICK1 PTEN PTPRD PTPRF
Entrez ID		54	2239
HPRD ID		01374	02160
Ensembl ID		ENSG00000102575	ENSG00000076716
Uniprot IDs		A0A024R7F8 P13686	O75487
PDB IDs		1WAR 2BQ8
Enriched GO Terms of Interacting Partners?
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