PPIL3 and ALS2

Data Source:
BioGRID (biochemical)

		PPIL3	ALS2
Description		peptidylprolyl isomerase like 3	alsin Rho guanine nucleotide exchange factor ALS2
Image			No pdb structure
GO Annotations	Cellular Component	Catalytic Step 2 Spliceosome	Ruffle Nucleus Early Endosome Centrosome Cytosol Lamellipodium Dendrite Growth Cone Vesicle Protein-containing Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding	Endosome Organization Lysosomal Transport Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Protein Homooligomerization Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		mRNA Splicing - Major Pathway	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Juvenile primary lateral sclerosis
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)	Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Perceived intensity of sweet substances ( 31005972)
Interacting Genes		6 interacting genes: CENATAC PCBP1 SHARPIN SLU7 TAB2 TAB3	1 interacting genes: YWHAB
Entrez ID		53938	57679
HPRD ID		15163	05893
Ensembl ID		ENSG00000240344	ENSG00000003393
Uniprot IDs		A0A024R3V4 A0A0S2Z5A8 Q9H2H8	A8K4R4 Q96Q42
PDB IDs		1XYH 2OJU 2OK3
Enriched GO Terms of Interacting Partners?
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