RAB4B and CDC45

Data Source:
BioGRID (two hybrid)

		RAB4B	CDC45
Description		RAB4B, member RAS oncogene family	cell division cycle 45
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GO Annotations	Cellular Component	Endosome Plasma Membrane Secretory Granule Membrane Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body
	Molecular Function	Molecular_function GTPase Activity Protein Binding GTP Binding	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding
	Biological Process	Protein Transport Regulation Of Endocytosis Rab Protein Signal Transduction Neutrophil Degranulation Glucose Import	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Mitotic DNA Replication Preinitiation Complex Assembly
Pathways		Neutrophil degranulation RAB geranylgeranylation MET receptor recycling	Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Carotid intima media thickness (mean) ( 31801372) Chronic obstructive pulmonary disease ( 22080838 28166215) Emphysema imaging phenotypes ( 26030696) Eosinophil percentage of white cells ( 32888494) Hematocrit ( 32888494) Hemoglobin ( 32888494) Kawasaki disease ( 22081228) Red blood cell count ( 32888494) Smoking behaviour (cigarettes smoked per day) ( 30617275)	Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		9 interacting genes: BOLA2 BOLA2B CDC45 EXOC5 FAM71C RAB7A RABAC1 RABEP1 VPS52	25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1
Entrez ID		53916	8318
HPRD ID		11473	09145
Ensembl ID		ENSG00000167578	ENSG00000093009
Uniprot IDs		A0A024R0K8 P61018	O75419
PDB IDs		2O52	5DGO 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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