PCSK2 and PMCH

Data Source:
HPRD (in vivo)

		PCSK2	PMCH
Description		proprotein convertase subtilisin/kexin type 2	pro-melanin concentrating hormone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Membrane Transport Vesicle Secretory Granule Dendrite Neuron Projection Perikaryon Intracellular Membrane-bounded Organelle	Extracellular Region Nucleus Synapse
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Protein-containing Complex Binding	Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding
	Biological Process	Proteolysis Nervous System Development Protein Processing Peptide Hormone Processing Protein Autoprocessing Insulin Processing Enkephalin Processing Islet Amyloid Polypeptide Processing	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Multicellular Organism Development Spermatogenesis Behavior Feeding Behavior Cell Differentiation
Pathways		Insulin processing	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		Insulin pork
Diseases
GWAS		Biochemical measures ( 19260141) Body size at age 10 ( 32376654) Chronotype ( 30696823) Dialysis-related mortality ( 21546767) Familial lung cancer ( 29924316) Loneliness ( 27629369) Menarche (age at onset) ( 21102462 25231870) Morning person ( 30696823) Obesity-related traits ( 23251661) Preschool internalizing problems ( 24839885) Response to fenofibrate (triglyceride levels) ( 27002377)	Adventurousness ( 30643258) Brain morphology (MOSTest) ( 32665545) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 19893584) Number of sexual partners ( 30643258)
Interacting Genes		3 interacting genes: IAPP PMCH SCG5	10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7
Entrez ID		5126	5367
HPRD ID		01202	01459
Ensembl ID		ENSG00000125851	ENSG00000183395
Uniprot IDs		P16519	P20382
PDB IDs
Enriched GO Terms of Interacting Partners?
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