PLXNA1 and NRP1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PLXNA1	NRP1
Description		plexin A1	neuropilin 1
Image		No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome	Semaphorin Receptor Complex Extracellular Space Early Endosome Cytosol Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Axon Growth Cone Cytoplasmic Vesicle Mitochondrial Membrane Neuron Projection Neuronal Cell Body Receptor Complex Sorting Endosome
	Molecular Function	Semaphorin Receptor Activity Signaling Receptor Activity	Vascular Endothelial Growth Factor-activated Receptor Activity GTPase Activator Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Cell Adhesion Multicellular Organism Development Regulation Of Cell Shape Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Migration Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Neuron Projection Extension	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Integrin-mediated Signaling Pathway Cell-cell Signaling Axon Guidance Response To Wounding Animal Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Nerve Development Retinal Ganglion Cell Axon Guidance Actin Cytoskeleton Reorganization Regulation Of Cdc42 Protein Signal Transduction Substrate Adhesion-dependent Cell Spreading Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Neuropilin Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Positive Regulation Of Phosphorylation Endothelial Cell Migration Positive Regulation Of GTPase Activity Viral Entry Into Host Cell Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Cytokine Activity Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Angiogenesis Involved In Coronary Vascular Morphogenesis Retina Vasculature Morphogenesis In Camera-type Eye Sympathetic Ganglion Development Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Retinal Ganglion Cell Axon Guidance Endothelial Tip Cell Fate Specification Motor Neuron Migration Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Basal Dendrite Development Basal Dendrite Arborization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Positive Regulation Of Retinal Ganglion Cell Axon Guidance Protein Localization To Early Endosome Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions	Neurophilin interactions with VEGF and VEGFR Signaling by ROBO receptors Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Signal transduction by L1 CHL1 interactions
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576 29875488) Platelet count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 31469255) Weight ( 28552196) Whole-brain volume ( 21116278)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Migraine ( 27322543) Reticulocyte count ( 32888494) Schizophrenia ( 21682944) Small cell lung carcinoma ( 28604730) Tetralogy of Fallot ( 23297363)
Interacting Genes		9 interacting genes: AKT1 FES L1CAM NRP1 NRP2 PLXNB1 RHOD RND1 SEMA6D	23 interacting genes: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 PLXNB1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F TGFBR1 TGFBR2 TGFBR3 VEGFA VEGFB
Entrez ID		5361	8829
HPRD ID		11868	03642
Ensembl ID		ENSG00000114554	ENSG00000099250
Uniprot IDs		Q9UIW2	A8K9V7 O14786 Q59F20 Q68DN3 Q6AWA9 Q6X907
PDB IDs			1KEX 2QQI 2QQM 2QQN 3I97 4DEQ 4RN5 5C7G 5IJR 5IYY 5J1X 5JGI 5JGQ 5JHK 5L73 6FMC 6FMF 7JJC
Enriched GO Terms of Interacting Partners?
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