FXYD3 and AQP9

Data Source:
BioGRID (two hybrid)

		FXYD3	AQP9
Description		FXYD domain containing ion transport regulator 3	aquaporin 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Chloride Channel Activity Sodium Channel Regulator Activity Ion Channel Regulator Activity	Amine Transmembrane Transporter Activity Purine Nucleobase Transmembrane Transporter Activity Pyrimidine Nucleobase Transmembrane Transporter Activity Water Transmembrane Transporter Activity Protein Binding Polyol Transmembrane Transporter Activity Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Urea Channel Activity Carboxylic Acid Transmembrane Transporter Activity
	Biological Process	Potassium Ion Transport Sodium Ion Transport Chloride Transport Ion Transmembrane Transport Chloride Transmembrane Transport Regulation Of Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Water Transport Purine Nucleobase Transport Response To Osmotic Stress Excretion Response To Organic Substance Canalicular Bile Acid Transport Polyol Transport Glycerol Transport Amine Transport Pyrimidine Nucleobase Transport Water Homeostasis Response To Mercury Ion Carboxylic Acid Transport Cellular Response To CAMP Urea Transmembrane Transport Pyrimidine-containing Compound Transmembrane Transport Purine Nucleobase Transmembrane Transport Carboxylic Acid Transmembrane Transport
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins
Drugs
Diseases
GWAS			Glycine levels ( 30837465) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Ischemic stroke ( 26089329) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 23823483 22916037) Small cell lung carcinoma ( 28604730) Stroke ( 26089329) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		64 interacting genes: AGR3 ANK1 AQP6 AQP9 BCL2L13 BEST2 CD79A CNR2 CREB3 CREB3L1 CYB5R3 EBP ERG28 ERGIC3 FAM209A FBXL12 FCGR2A FFAR2 GHITM GPR152 GPR37L1 GPR42 GPRC5D IBSP KASH5 KCNN4 LMNA LTC4S MAPK6 MFSD11 MFSD5 MGST1 MTIF3 NR4A1 NUDT3 PLPP6 SCN3B SERBP1 SGPL1 SLC10A1 SLC10A6 SLC16A12 SLC18A1 SLC1A1 SLC30A2 SLC35A1 SLC35B1 SLC35C2 SLC39A2 SPNS3 STRIT1 STX3 TIMM23 TIMMDC1 TLCD1 TMBIM6 TMEM179B TMEM50B TMEM52B TMEM80 TMEM86A TMEM97 TSPO2 XKR3	24 interacting genes: ADAM33 AIG1 APOD CCDC167 CLDN19 CPLX4 CTXN3 CXCL16 EMC6 FATE1 FXYD3 FZD7 GAST HHLA2 IGFBP5 LHFPL5 MIP PAEP SERINC1 SGPL1 SLC38A7 TF TMED9 TMEM109
Entrez ID		5349	366
HPRD ID		05410	04223
Ensembl ID		ENSG00000089356	ENSG00000103569
Uniprot IDs		Q14802	H0YK62 O43315
PDB IDs
Enriched GO Terms of Interacting Partners?
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