PLIN1 and BSCL2

Data Source:
BioGRID (affinity chromatography technology, protein complementation assay)

		PLIN1	BSCL2
Description		perilipin 1	BSCL2 lipid droplet biogenesis associated, seipin
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Lipid Binding	Protein Binding Phospholipid Binding
	Biological Process	Lipid Metabolic Process Lipid Catabolic Process	Lipid Catabolic Process Lipid Storage Lipid Droplet Organization Fat Cell Differentiation Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Cold-induced Thermogenesis Lipid Droplet Formation
Pathways		Triglyceride catabolism Transcriptional regulation of white adipocyte differentiation NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
Drugs
Diseases			Hereditary spastic paraplegia (SPG) Congenital generalized lipodystrophy (CGL) Distal hereditary motor neuropathies (dHMN)
GWAS		HDL cholesterol ( 30275531)	Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: ABHD5 BSCL2 LIPE PRKACA	38 interacting genes: ANKRD46 B4GALNT2 BMP10 CLDN19 CMTM7 CPEB2 CXCL9 CYSRT1 ERMP1 FAM20B GABARAPL1 GMCL1 HOXA1 KRTAP6-3 LAT MALL NSG1 OLFM4 PLEKHF2 PLIN1 RPRM SERP1 SERP2 SFTPC SMIM3 SMLR1 STRIT1 TEX37 TMEM19 TMEM218 TMEM222 TRAM1L1 TRARG1 TRIM54 TSPAN2 UPK2 USE1 VAMP3
Entrez ID		5346	26580
HPRD ID		01364	05858
Ensembl ID		ENSG00000166819	ENSG00000168000
Uniprot IDs		O60240	A0A024R540 A0A024R549 Q96G97
PDB IDs			6DS5
Enriched GO Terms of Interacting Partners?
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