BSCL2 and PLIN1

Data Source:
BioGRID (affinity chromatography technology, protein complementation assay)

		BSCL2	PLIN1
Description		BSCL2 lipid droplet biogenesis associated, seipin	perilipin 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Protein Binding Phospholipid Binding	Lipid Binding
	Biological Process	Lipid Catabolic Process Lipid Storage Lipid Droplet Organization Fat Cell Differentiation Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Cold-induced Thermogenesis Lipid Droplet Formation	Lipid Metabolic Process Lipid Catabolic Process
Pathways			Triglyceride catabolism Transcriptional regulation of white adipocyte differentiation NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
Drugs
Diseases		Hereditary spastic paraplegia (SPG) Congenital generalized lipodystrophy (CGL) Distal hereditary motor neuropathies (dHMN)
GWAS		Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	HDL cholesterol ( 30275531)
Interacting Genes		38 interacting genes: ANKRD46 B4GALNT2 BMP10 CLDN19 CMTM7 CPEB2 CXCL9 CYSRT1 ERMP1 FAM20B GABARAPL1 GMCL1 HOXA1 KRTAP6-3 LAT MALL NSG1 OLFM4 PLEKHF2 PLIN1 RPRM SERP1 SERP2 SFTPC SMIM3 SMLR1 STRIT1 TEX37 TMEM19 TMEM218 TMEM222 TRAM1L1 TRARG1 TRIM54 TSPAN2 UPK2 USE1 VAMP3	4 interacting genes: ABHD5 BSCL2 LIPE PRKACA
Entrez ID		26580	5346
HPRD ID		05858	01364
Ensembl ID		ENSG00000168000	ENSG00000166819
Uniprot IDs		A0A024R540 A0A024R549 Q96G97	O60240
PDB IDs		6DS5
Enriched GO Terms of Interacting Partners?
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