ATP6V0B and DAPK2

Data Source:
BioGRID (affinity chromatography technology)

		ATP6V0B	DAPK2
Description		ATPase H+ transporting V0 subunit b	death associated protein kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Vacuolar Membrane Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain	Nucleus Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Autophagosome Lumen Intracellular Membrane-bounded Organelle
	Molecular Function	Transporter Activity Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism	Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Phagosome Acidification Proton Transmembrane Transport	Protein Phosphorylation Apoptotic Process Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Anoikis Protein Autophosphorylation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Eosinophil Chemotaxis Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Caspase activation via Dependence Receptors in the absence of ligand
Drugs		Tiludronic acid	Fostamatinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Arterial stiffness index ( 31235810) Blood protein levels ( 28240269) Cerebral amyloid deposition (PET imaging) ( 30361487) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) HDL cholesterol levels ( 32203549) Platelet distribution width ( 27863252) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Triglyceride levels ( 31647587) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		28 interacting genes: ADGRG3 ADRB2 APOD COL4A5 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 VMA21 YWHAE YWHAG	6 interacting genes: APP CAMK2A CCDC91 FAM9B MLC1 TGFBR1
Entrez ID		533	23604
HPRD ID		04759	09905
Ensembl ID		ENSG00000117410	ENSG00000035664
Uniprot IDs		E9PNL3 Q99437	A0A024R603 Q9UIK4
PDB IDs			1WMK 1WRZ 1Z9X 1ZUZ 1ZWS 2A27 2A2A 2CKE 6PAW
Enriched GO Terms of Interacting Partners?
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