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PLA2G2A and DCN
Data Source:
HPRD
(in vivo, in vitro)
PLA2G2A
DCN
Description
phospholipase A2 group IIA
decorin
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Secretory Granule
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Extracellular Region
Collagen Type VI Trimer
Extracellular Space
Golgi Lumen
Lysosomal Lumen
Collagen-containing Extracellular Matrix
Molecular Function
Phospholipase A2 Activity
Calcium Ion Binding
Phospholipid Binding
Calcium-dependent Phospholipase A2 Activity
Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine)
Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
RNA Binding
Protein Binding
Collagen Binding
Glycosaminoglycan Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Protein N-terminus Binding
Extracellular Matrix Binding
Biological Process
Phospholipid Metabolic Process
Phosphatidic Acid Biosynthetic Process
Inflammatory Response
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Lipid Catabolic Process
Antimicrobial Humoral Response
Cytolysis
Low-density Lipoprotein Particle Remodeling
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylinositol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Intestinal Stem Cell Homeostasis
Phosphatidylethanolamine Metabolic Process
Phosphatidylcholine Metabolic Process
Phosphatidic Acid Metabolic Process
Arachidonic Acid Secretion
Positive Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Neutrophil Activation
Kidney Development
Placenta Development
Skeletal Muscle Tissue Development
Aging
Response To Mechanical Stimulus
Animal Organ Morphogenesis
Positive Regulation Of Autophagy
Negative Regulation Of Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Macroautophagy
Negative Regulation Of Angiogenesis
Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan
Extracellular Matrix Organization
Chondroitin Sulfate Biosynthetic Process
Chondroitin Sulfate Catabolic Process
Dermatan Sulfate Biosynthetic Process
Response To Lipopolysaccharide
Wound Healing
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitochondrial Depolarization
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Antimicrobial peptides
Degradation of the extracellular matrix
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
ECM proteoglycans
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective CHST14 causes EDS, musculocontractural type
Defective CHSY1 causes TPBS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Indomethacin
Ginkgo biloba
1,4-Butanediol
1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene
N-Tridecanoic Acid
[3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid
4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid
Lauric acid
(1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid
6-phenyl-4(R)-(7-phenyl-heptanoylamino)-hexanoic acid
Elaidamide
(2R)-2-Acetamido-3-(octadecyloxy)propyl 2-(methylsulfanyl)ethyl hydrogen phosphate
KH064
Suramin
Varespladib methyl
Diseases
Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy
GWAS
Blood protein levels (
30072576
29875488
)
group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP (
31070471
)
Immunoglobulin light chain (AL) amyloidosis (
28025584
)
Blood protein levels (
30072576
)
Central corneal thickness (
32528159
29760442
)
Heel bone mineral density (
30598549
)
Intraocular pressure (
29617998
)
Refractive error (
32231278
)
Sudden cardiac arrest (
21658281
)
Interacting Genes
26 interacting genes:
ALOX12
BAG6
CEP70
CRMP1
DCN
ITGAV
ITGB3
JOSD2
PLA2G1B
PLA2R1
SENP6
SENP8
UCHL1
UCHL3
UCHL5
USP15
USP2
USP20
USP28
USP4
USP47
USP5
USP7
USP8
VCAN
VIM
30 interacting genes:
AHSG
BRCA1
C1QA
CCN4
COL14A1
COL1A1
COL1A2
COL4A1
COL4A3
COL4A4
COL4A5
COL4A6
COL5A1
COL6A1
DPT
EGFR
ELN
FBN1
FLNA
FN1
MET
MMP2
MMP3
MMP7
PLA2G2A
SFTPD
TGFB1
TGFB2
THBS1
TNF
Entrez ID
5320
1634
HPRD ID
01397
00501
Ensembl ID
ENSG00000188257
ENSG00000011465
Uniprot IDs
A0A024RA96
P14555
A0A024RBG6
P07585
Q6FH10
PDB IDs
1AYP
1BBC
1DB4
1DB5
1DCY
1J1A
1KQU
1KVO
1N28
1N29
1POD
1POE
2GNY
3U8B
3U8D
3U8H
3U8I
5G3N
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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