DCN and TGFB2

Data Source:
BioGRID (pull down)

		DCN	TGFB2
Description		decorin	transforming growth factor beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VI Trimer Extracellular Space Golgi Lumen Lysosomal Lumen Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Axon Platelet Alpha Granule Lumen Neuronal Cell Body Collagen-containing Extracellular Matrix
	Molecular Function	RNA Binding Protein Binding Collagen Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Protein N-terminus Binding Extracellular Matrix Binding	Amyloid-beta Binding Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity
	Biological Process	Kidney Development Placenta Development Skeletal Muscle Tissue Development Aging Response To Mechanical Stimulus Animal Organ Morphogenesis Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Macroautophagy Negative Regulation Of Angiogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Response To Lipopolysaccharide Wound Healing Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Fission Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway	Cell Morphogenesis Skeletal System Development Eye Development Response To Hypoxia Kidney Development Epithelial To Mesenchymal Transition Neural Tube Closure Hair Follicle Development Platelet Degranulation Heart Morphogenesis Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Heart Valve Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Endocardial Cushion Fusion Atrial Septum Primum Morphogenesis Neural Retina Development Protein Phosphorylation Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Salivary Gland Morphogenesis Heart Development Cell Death Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Glial Cell Migration Male Gonad Development Response To Wounding Embryo Development Ending In Birth Or Egg Hatching Cardioblast Differentiation Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Negative Regulation Of Angiogenesis Hemopoiesis Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis BMP Signaling Pathway Neutrophil Chemotaxis Hair Follicle Morphogenesis Activation Of Protein Kinase Activity Response To Progesterone Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Cell Adhesion Mediated By Integrin Ascending Aorta Morphogenesis Wound Healing Regulation Of Cell Population Proliferation Dopamine Biosynthetic Process Odontogenesis Response To Drug Uterine Wall Breakdown Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Ossification Positive Regulation Of Cell Cycle Positive Regulation Of Heart Contraction Negative Regulation Of Ras Protein Signal Transduction Somatic Stem Cell Division Embryonic Digestive Tract Development Neuron Development Generation Of Neurons Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Positive Regulation Of Cell Division Regulation Of Timing Of Catagen Positive Regulation Of Timing Of Catagen Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Proliferation Uterus Development Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Pharyngeal Arch Artery Morphogenesis Secondary Palate Development Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Complement-dependent Cytotoxicity Substantia Propria Of Cornea Development Cranial Skeletal System Development Negative Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Pathways		Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	Platelet degranulation Molecules associated with elastic fibres ECM proteoglycans
Drugs
Diseases		Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy	Graft-versus-host disease Allograft rejection
GWAS		Blood protein levels ( 30072576) Central corneal thickness ( 32528159 29760442) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998) Refractive error ( 32231278) Sudden cardiac arrest ( 21658281)	Acne (severe) ( 24927181 30542056) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone mineral density (hip) ( 30172743) Central corneal thickness ( 32528159 29760442) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease (severe) ( 24621683) Diastolic blood pressure ( 30224653) Diffusing capacity of carbon monoxide ( 30694715) Emphysema imaging phenotypes ( 26030696) FEV1 ( 30804560) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 25673412) Hip minimal joint space width ( 27701424) Intraocular pressure ( 29617998) Local histogram emphysema pattern ( 25006744) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Systolic blood pressure ( 30578418) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		30 interacting genes: AHSG BRCA1 C1QA CCN4 COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SFTPD TGFB1 TGFB2 THBS1 TNF	15 interacting genes: APP BMP2 CCN2 DCN ENG FMOD LTBP3 PZP TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBR3 VASN VTN
Entrez ID		1634	7042
HPRD ID		00501	01828
Ensembl ID		ENSG00000011465	ENSG00000092969
Uniprot IDs		A0A024RBG6 P07585 Q6FH10	P61812 Q59EG9
PDB IDs			1TFG 2TGI 4KXZ 5TX4 5TY4 6I9J
Enriched GO Terms of Interacting Partners?
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