PKHD1 and CAMLG

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PKHD1	CAMLG
Description		PKHD1 ciliary IPT domain containing fibrocystin/polyductin	calcium modulating ligand
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Cilium Integral Component Of Membrane Apical Plasma Membrane Anchored Component Of External Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle 9+0 Non-motile Cilium	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding Ubiquitin Protein Ligase Binding Cell Adhesion Molecule Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Kidney Development Regulation Of Cell-matrix Adhesion Epithelial Cell Morphogenesis Cellular Calcium Ion Homeostasis Positive Regulation Of Cell Population Proliferation Regulation Of Centrosome Duplication Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of TOR Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Homeostatic Process Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Component Movement Establishment Of Centrosome Localization Negative Regulation Of Protein Kinase B Signaling Cilium Assembly Regulation Of ERK1 And ERK2 Cascade Regulation Of Establishment Of Planar Polarity Cell-cell Adhesion Negative Regulation Of Epithelial Cell Apoptotic Process Regulation Of Cholangiocyte Proliferation	Defense Response Signal Transduction Viral Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Stabilization
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			Cyclosporine
Diseases		Polycystic kidney disease
GWAS		Adult body size ( 32376654) Alcohol use disorder ( 30940813) Body size at age 10 ( 32376654) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronotype ( 30696823) Coffee consumption ( 31046077) Diastolic blood pressure ( 28135244 27841878) Epigenetic age acceleration in alcohol use disorder ( 31466081) Estimated glomerular filtration rate ( 31152163) Fruit consumption ( 32066663) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 24002674 29785010 31959993 30054594 29235454) Longevity ( 30294719) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 17903305) Red vs. brown/black hair color ( 30531825) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Tea consumption ( 31046077) Urinary sodium excretion ( 31409800) Waist circumference ( 19557197) Weight loss (gastric bypass surgery) ( 23633212)	Height ( 18391951)
Interacting Genes		1 interacting genes: CAMLG	22 interacting genes: ADIPOQ AGR2 EGFR ETNK1 F11R GET1 GET3 HSP90B1 KCNA2 KCNE4 LAT LCN2 OCIAD1 PBXIP1 PGRMC1 PKHD1 PPIB RPN1 TMEM31 TNFRSF13B TXNDC12 VWC2
Entrez ID		5314	819
HPRD ID		05987	03073
Ensembl ID		ENSG00000170927	ENSG00000164615
Uniprot IDs		P08F94	P49069
PDB IDs			6SO5
Enriched GO Terms of Interacting Partners?
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