PIK3C3 and STYK1

Data Source:
BioGRID (pull down, affinity chromatography technology, pull down)

		PIK3C3	STYK1
Description		phosphatidylinositol 3-kinase catalytic subunit type 3	serine/threonine/tyrosine kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Endosome Late Endosome Peroxisome Cytosol Axoneme Membrane Midbody Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Autolysosome	Plasma Membrane Integral Component Of Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol Kinase Activity	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding
	Biological Process	Autophagosome Assembly Protein Lipidation Phosphatidylinositol Biosynthetic Process Endocytosis Autophagy Cell Cycle Macroautophagy Autophagy Of Peroxisome Regulation Of Cytokinesis Toll-like Receptor 9 Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Early Endosome To Late Endosome Transport Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling Cell Division	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Innate Immune Response
Pathways		PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs		N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide
Diseases
GWAS		Adult body size ( 32376654) Blood trace element (Zn levels) ( 23720494) Body size at age 10 ( 32376654) General risk tolerance (MTAG) ( 30643258) Obese vs. thin ( 30677029) Obesity-related traits ( 23251661) Periodontitis (PAL4Q3) ( 24024966)
Interacting Genes		8 interacting genes: CALM1 CASP8 FBXL20 PIK3R4 PITPNA STYK1 YWHAG YWHAQ	5 interacting genes: ATG14 BECN1 DUXAP9 ERBB2 PIK3C3
Entrez ID		5289	55359
HPRD ID		04009	15447
Ensembl ID		ENSG00000078142	ENSG00000060140
Uniprot IDs		A8MYT4 B4DPV9 Q8NEB9	Q6J9G0
PDB IDs		3IHY 3LS8 4OYS 4PH4 4UWF 4UWG 4UWH 4UWK 4UWL 5ANL 5ENN 6I3U
Enriched GO Terms of Interacting Partners?
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