PIK3C3 and PITPNA

Data Source:
HPRD (in vitro, in vivo)

		PIK3C3	PITPNA
Description		phosphatidylinositol 3-kinase catalytic subunit type 3	phosphatidylinositol transfer protein alpha
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Endosome Late Endosome Peroxisome Cytosol Axoneme Membrane Midbody Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Autolysosome	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol Kinase Activity	Protein Binding Phosphatidylcholine Transporter Activity Phosphatidylinositol Transfer Activity Phosphatidylcholine Binding Phosphatidylinositol Binding Phosphatidylcholine Transfer Activity Phosphatidylglycerol Binding
	Biological Process	Autophagosome Assembly Protein Lipidation Phosphatidylinositol Biosynthetic Process Endocytosis Autophagy Cell Cycle Macroautophagy Autophagy Of Peroxisome Regulation Of Cytokinesis Toll-like Receptor 9 Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Early Endosome To Late Endosome Transport Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling Cell Division	Lipid Metabolic Process Visual Perception Phospholipid Transport Interleukin-12-mediated Signaling Pathway Intermembrane Lipid Transfer
Pathways		PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Role of second messengers in netrin-1 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide	1,2-diacyl-sn-glycero-3-phosphoinositol (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
Diseases
GWAS		Adult body size ( 32376654) Blood trace element (Zn levels) ( 23720494) Body size at age 10 ( 32376654) General risk tolerance (MTAG) ( 30643258) Obese vs. thin ( 30677029) Obesity-related traits ( 23251661) Periodontitis (PAL4Q3) ( 24024966)	Metabolite levels ( 23823483) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		8 interacting genes: CALM1 CASP8 FBXL20 PIK3R4 PITPNA STYK1 YWHAG YWHAQ	8 interacting genes: CSNK2B DCC EGFR NEO1 PI4KA PIK3C3 PLCG1 SCP2
Entrez ID		5289	5306
HPRD ID		04009	02548
Ensembl ID		ENSG00000078142	ENSG00000174238
Uniprot IDs		A8MYT4 B4DPV9 Q8NEB9	Q00169 V9HWC5
PDB IDs		3IHY 3LS8 4OYS 4PH4 4UWF 4UWG 4UWH 4UWK 4UWL 5ANL 5ENN 6I3U	1UW5
Enriched GO Terms of Interacting Partners?
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