PHYH and TOM1L1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PHYH	TOM1L1
Description		phytanoyl-CoA 2-hydroxylase	target of myb1 like 1 membrane trafficking protein
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GO Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Matrix Cytosol 9+0 Non-motile Cilium	Cytoplasm Lysosome Endosome Golgi Stack Cytosol Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Ferrous Iron Binding Carboxylic Acid Binding L-ascorbic Acid Binding Phytanoyl-CoA Dioxygenase Activity	Protein Binding SH3 Domain Binding Protein Kinase Binding Clathrin Binding Protein Kinase Activator Activity Ubiquitin Binding
	Biological Process	Fatty Acid Alpha-oxidation 2-oxoglutarate Metabolic Process Protein Targeting To Peroxisome Isoprenoid Metabolic Process 2-oxobutyrate Catabolic Process Methyl-branched Fatty Acid Metabolic Process	Intracellular Protein Transport Signal Transduction Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process
Pathways		Alpha-oxidation of phytanate Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		Antihemophilic factor, human recombinant Ascorbic acid Lonoctocog alfa Moroctocog alfa
Diseases		Refsum disease; Heredopathia atactica polyneuritiformis
GWAS			Carotid intima media thickness x smoking interaction ( 32117412) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Urinary albumin-to-creatinine ratio ( 32600054)
Interacting Genes		11 interacting genes: ACSL6 APP F8 FAM9B FKBP4 MAGEA11 PATJ PEX7 PHYHIP SIRPA TOM1L1	29 interacting genes: AMFR CCDC47 CELF1 COPS7A CWF19L1 DNAJB13 FYN GLUD2 GRB2 GSN HGS HNRNPH1 MAP3K3 NDC80 NOMO1 PDPN PELP1 PHYH PIK3R1 PWP2 RAB18 TASOR TOLLIP TSG101 TUBA1B UBC UBXN4 VAV2 VCP
Entrez ID		5264	10040
HPRD ID		03609	05266
Ensembl ID		ENSG00000107537	ENSG00000141198
Uniprot IDs		O14832	O75674 Q8NI65
PDB IDs		2A1X	3RRU
Enriched GO Terms of Interacting Partners?
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