INPP5K and ANXA7

Data Source:
BioGRID (two hybrid)

		INPP5K	ANXA7
Description		inositol polyphosphate-5-phosphatase K	annexin A7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endoplasmic Reticulum Trans-Golgi Network Cytosol Plasma Membrane Membrane Ruffle Membrane Neuron Projection Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Membrane Chromaffin Granule Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Vasopressin Receptor Activity Protein Binding Inositol Bisphosphate Phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Trisphosphate Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Lipid Phosphatase Activity Inositol Trisphosphate Phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity	RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Calcium-dependent Protein Binding
	Biological Process	In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Protein Kinase Activity Phosphatidylinositol Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Glucose Transmembrane Transport Dephosphorylation Actin Cytoskeleton Organization Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Dephosphorylation Positive Regulation Of Urine Volume Glucose Homeostasis Negative Regulation Of MAP Kinase Activity Negative Regulation By Host Of Viral Transcription Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Receptor Signaling Pathway Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Calcium Ion Transport Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Protein Targeting To Membrane Ruffle Assembly Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Renal Water Transport	Autophagy Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Epithelial Cell Differentiation Response To Calcium Ion Membrane Fusion
Pathways		Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Mean platelet volume ( 27863252)	Copper levels ( 26025379)
Interacting Genes		23 interacting genes: ANXA7 ARL6IP1 ATP5PF BDNF CDKN1A CPTP FADS6 FATE1 FBXO7 GOLT1B HMOX2 HSPB1 KRT31 MAD2L1BP NCOR2 PBX3 PFDN1 SFT2D2 SMN1 TANK TK1 TNFRSF10D TTR	107 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 ANGPT2 APC APLP1 ATP5F1B ATP6V1A ATXN3 BAG6 CCDC90B CCT7 CDK4 CELF3 CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE2 CPNE6 CRMP1 CSAD CTSB DDAH2 DMPK DOCK7 DVL1 DYNC1I1 EEF1A1 ERG28 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GAPDH GBP2 GDF9 GNB2 GNB5 HADHB HMGXB3 HOXD8 INPP5K INTS11 KLHL23 KMT2B LRIF1 MED31 MPPED1 MSH2 NGFR NMT2 NPRL2 OTUB1 PAAF1 PAX8 PDCD6 PDHB PKM PLD3 PRKACA PRKCA PRKCB PRKCG PRKG1 PSMB10 QARS1 RBBP4 RBM48 RPA1 RPL13 RPS2 S100A10 SDF4 SEMA5B SETDB1 SMPD1 SP110 SRC SRI SUMO3 TAF5L TIAM2 TLE1 TMEM108 TMSB4X TRMT2A TUBA1A TUBB2B TUBB3 UBE2D1 UCHL5 UNC119 USP4 VIM WDR18 WDR73 ZBTB16 ZNF135 ZNF431
Entrez ID		51763	310
HPRD ID		08489	01720
Ensembl ID		ENSG00000132376	ENSG00000138279
Uniprot IDs		B7Z4V9 Q9BT40	B2R657 P20073
PDB IDs
Enriched GO Terms of Interacting Partners?
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