RAPGEF6 and ABCA1

Data Source:
HPRD (in vitro)

		RAPGEF6	ABCA1
Description		Rap guanine nucleotide exchange factor 6	ATP binding cassette subfamily A member 1
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GO Annotations	Cellular Component	Centrosome Cytosol Plasma Membrane Apical Plasma Membrane Endocytic Vesicle	Endosome Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm Intracellular Vesicle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP-dependent Protein Binding Small GTPase Binding Phosphatidic Acid Binding	Signaling Receptor Binding Lipid Transporter Activity Protein Binding ATP Binding Phospholipid Transporter Activity Protein Transmembrane Transporter Activity Cholesterol Binding ATPase Activity Syntaxin Binding Phosphatidylcholine Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase-coupled Transmembrane Transporter Activity Sphingolipid Floppase Activity ATPase Binding Phosphatidylcholine Floppase Activity Phosphatidylserine Floppase Activity Cholesterol Transfer Activity Floppase Activity
	Biological Process	Ras Protein Signal Transduction Microvillus Assembly Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier	Lipid Transport Lysosome Organization G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cholesterol Metabolic Process Protein Secretion Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Endosomal Transport Regulation Of Lipid Metabolic Process Signal Release Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Cholesterol Homeostasis Reverse Cholesterol Transport Phospholipid Translocation Phospholipid Homeostasis Platelet Dense Granule Organization Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Transmembrane Transport Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of High-density Lipoprotein Particle Assembly Sphingolipid Translocation Intermembrane Lipid Transfer Export Across Plasma Membrane
Pathways			PPARA activates gene expression Defective ABCA1 causes TGD HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs			ATP Glyburide Probucol
Diseases			Tangier disease Hypoalphalipoproteinemia
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 32296059) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Subjective well-being ( 27089181) Ulcerative colitis ( 28067908)	Advanced age-related macular degeneration ( 26691988) Allergic rhinitis ( 25085501) Aluminium levels ( 26025379) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Cardiometabolic and hematological traits ( 27668658) Cholesterol, total ( 24097068 25961943 20686565 26582766) Coronary artery disease ( 29212778 33020668) Glaucoma ( 30104761 31959993 30054594) Glaucoma (high intraocular pressure) ( 25173107) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 25173105 29452408) Gout ( 22179738) HDL cholesterol ( 24097068 21909109 28270201 18193043 18193044 20864672 26160806 19060906 23505323 19060911 30275531 21347282 25961943 26780889 20686565 26582766) HDL cholesterol levels ( 32203549 31694877 28334899 26690388 31087446 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 30718733 29403010 29615537) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) HOMA-B (corrected for HOMA-IR) ( 30369944) Intraocular pressure ( 29617998 25173106 31798171 29785010 31959993 30054594 28073927 30591961 29235454) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219) Low density lipoprotein cholesterol levels ( 32154731) Low high density lipoprotein cholesterol levels ( 26879886) Lung cancer in ever smokers ( 28604730) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 31589552) Metabolite levels ( 31628463 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Myopia (pathological) ( 23049088) Pelvic organ prolapse ( 26545240) Periodontitis (Mean PAL) ( 24024966) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to fenofibrate (total cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Total cholesterol levels ( 28334899 31087446 29403010 30275531) Triglyceride levels ( 32203549 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Type 2 diabetes ( 32499647) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		8 interacting genes: ABCA1 LINC00839 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG	41 interacting genes: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBIN FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ PALS2 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2
Entrez ID		51735	19
HPRD ID		11483	02501
Ensembl ID		ENSG00000158987	ENSG00000165029
Uniprot IDs		B2RTU6 Q8TEU7	B2RUU2 B7XCW9 O95477
PDB IDs		2D93 3LNY	5XJY
Enriched GO Terms of Interacting Partners?
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