POLR3K and TRIM69

Data Source:
BioGRID (two hybrid)

		POLR3K	TRIM69
Description		RNA polymerase III subunit K	tripartite motif containing 69
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm RNA Polymerase III Complex Nucleolus Cytosol	Nucleus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Nucleic Acid Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Zinc Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Transcription By RNA Polymerase III Termination Of RNA Polymerase III Transcription Positive Regulation Of Type I Interferon Production TRNA 3'-trailer Cleavage Innate Immune Response Defense Response To Virus	Protein Polyubiquitination Apoptotic Process Protein Ubiquitination
Pathways		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Mean corpuscular volume ( 32888494) Red blood cell traits ( 23446634)	Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		3 interacting genes: CENPP SDCBP TRIM69	53 interacting genes: AIFM2 APP ASNS ATP5MC1 BEX2 BIN3 C4orf45 CDSN DVL1 ETFDH FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483
Entrez ID		51728	140691
HPRD ID		16187	11518
Ensembl ID		ENSG00000161980	ENSG00000185880
Uniprot IDs		Q9Y2Y1	H0YL66 Q86WT6
PDB IDs			4NQJ 6YXE
Enriched GO Terms of Interacting Partners?
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