SUFU and GLI1

Data Source:
HPRD (in vivo, in vitro)

		SUFU	GLI1
Description		SUFU negative regulator of hedgehog signaling	GLI family zinc finger 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ciliary Tip Ciliary Base	Nucleus Nucleoplasm Cytoplasm Cytosol Axoneme Ciliary Tip Ciliary Base
	Molecular Function	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Microtubule Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Neural Tube Closure Heart Looping Ventricular Septum Development Regulation Of Transcription, DNA-templated Proteolysis Signal Transduction Multicellular Organism Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Aorta Development Negative Regulation Of Protein Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Skin Development Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Coronary Vasculature Development Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Response To Wounding Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Prostate Gland Development Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Notochord Regression Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Hepatocyte Proliferation
Pathways		Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state	Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
Diseases		Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome
GWAS		Adult body size ( 32376654) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergy ( 27182965) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Creatinine levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Height ( 28552196) Nickel levels ( 26025379) Optic disc size ( 31809533) Platelet count ( 32888494) Prostate cancer ( 23535732) Refractive error ( 32231278) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White blood cell count ( 29403010)
Interacting Genes		50 interacting genes: ABI3 BFSP2 BTRC CRTC2 CRX DISC1 FBXL17 FXR1 GLI1 GLI2 GLI3 GLIS3 HDX HMGA1 HNRNPA1 ITCH KRT27 KRT75 L3MBTL3 LAMTOR3 LCA5 LGALS3 LZTS1 MAGEL2 MEOX2 MID1IP1 NCOA3 PEX26 PIAS1 QPRT RBPJ RCN3 RNF19A SAP18 SETDB1 SH3RF1 SLC41A3 STK36 STX19 TLE5 UBE2D1 ZIC1 ZNF114 ZNF219 ZNF263 ZNF330 ZNF446 ZNF763 ZNF764 ZSCAN18	22 interacting genes: AQP1 CATSPER1 CRYBA4 DYRK1A FEM1B GCC1 IKBKB PIN1 PRKAA2 PRKACA PRMT1 PRMT5 RAI1 STK36 SUFU TAF9 TRIM42 USP48 WDR77 XBP1 ZIC1 ZIC2
Entrez ID		51684	2735
HPRD ID		06124	01311
Ensembl ID		ENSG00000107882	ENSG00000111087
Uniprot IDs		A0A223LX15 Q9UMX1	B4DNF7 P08151
PDB IDs		1M1L 4BL8 4BL9 4BLA 4BLB 4BLD 4KM8 4KM9 4KMD 4KMH	2GLI 4BLB 4KMD 5OM0
Enriched GO Terms of Interacting Partners?
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