ASB4 and HIF1AN

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)
HPRD (in vivo)

		ASB4	HIF1AN
Description		ankyrin repeat and SOCS box containing 4	hypoxia inducible factor 1 subunit alpha inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Notch Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding 2-oxoglutarate-dependent Dioxygenase Activity Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity Peptidyl-asparagine 3-dioxygenase Activity Protein Homodimerization Activity NF-kappaB Binding Ankyrin Repeat Binding Hypoxia-inducible Factor-asparagine Oxygenase Activity
	Biological Process	Intracellular Signal Transduction Post-translational Protein Modification Protein Autoubiquitination Positive Regulation Of Vasculogenesis	Protein Phosphopantetheinylation Peptidyl-histidine Hydroxylation Peptidyl-aspartic Acid Hydroxylation Peptidyl-asparagine Hydroxylation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Vasculogenesis
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Cellular response to hypoxia
Drugs			D-tartaric acid N-(carboxycarbonyl)-D-phenylalanine
Diseases
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Metabolite levels ( 23823483) Middle childhood and early adolescence aggressive behavior ( 26087016)	Body mass index ( 28892062 25673413) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Metabolite levels ( 23823483) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303)
Interacting Genes		3 interacting genes: HIF1AN ID2 UBE2D1	19 interacting genes: ANKK1 ANKRD12 ANKRD37 ANKRD50 ASB13 ASB4 ASB7 ASB9 FBF1 HDAC1 HDAC2 HDAC3 HIF1A INVS NAA10 SIAH1 TP53BP2 UACA VHL
Entrez ID		51666	55662
HPRD ID		05770	09426
Ensembl ID		ENSG00000005981	ENSG00000166135
Uniprot IDs		Q9Y574	Q9NWT6
PDB IDs			1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC 6H9J 6HA6 6HC8 6HKP 6HL5 6HL6 6RUJ
Enriched GO Terms of Interacting Partners?
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