PDK4 and PDHA1

Data Source:
HPRD (in vitro)

		PDK4	PDHA1
Description		pyruvate dehydrogenase kinase 4	pyruvate dehydrogenase E1 subunit alpha 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity
	Biological Process	Glucose Metabolic Process Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Cellular Response To Starvation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Response To Starvation Regulation Of Bone Resorption Regulation Of Fatty Acid Oxidation Cellular Response To Fatty Acid Reactive Oxygen Species Metabolic Process Negative Regulation Of Anoikis	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs		Tretinoin 4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol	NADH
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Refractive error ( 32231278)	Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: DLAT PDHA1 PLEKHF2 TRIM63	9 interacting genes: DLAT EIF6 HSD17B10 PDHB PDK1 PDK2 PDK3 PDK4 PDP1
Entrez ID		5166	5160
HPRD ID		03957	02420
Ensembl ID		ENSG00000004799	ENSG00000131828
Uniprot IDs		A4D1H4 Q16654	A0A024RBX9 P08559
PDB IDs		2E0A 2ZDX 2ZDY 2ZKJ 3D2R	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?
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