PDHA1 and PDK3

Data Source:
HPRD (in vitro)

		PDHA1	PDK3
Description		pyruvate dehydrogenase E1 subunit alpha 1	pyruvate dehydrogenase kinase 3
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GO Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex	Nucleolus Mitochondrion Mitochondrial Matrix
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate	Glucose Metabolic Process Protein Phosphorylation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Peptidyl-serine Phosphorylation Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid Hypoxia-inducible Factor-1alpha Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		NADH	Radicicol Dihydrolipoic Acid
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Metabolite levels ( 23823483)	Malaria ( 31844061)
Interacting Genes		9 interacting genes: DLAT EIF6 HSD17B10 PDHB PDK1 PDK2 PDK3 PDK4 PDP1	4 interacting genes: APP DLAT EGFR PDHA1
Entrez ID		5160	5165
HPRD ID		02420	03956
Ensembl ID		ENSG00000131828	ENSG00000067992
Uniprot IDs		A0A024RBX9 P08559	Q15120
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO	1Y8N 1Y8O 1Y8P 2PNR 2Q8I
Enriched GO Terms of Interacting Partners?
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