CDK5RAP1 and PPP1R16B

Data Source:
BioGRID (biochemical)

		CDK5RAP1	PPP1R16B
Description		CDK5 regulatory subunit associated protein 1	protein phosphatase 1 regulatory subunit 16B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Mitochondrion Cytosol	Nucleus Plasma Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Binding N6-isopentenyladenosine Methylthiotransferase Activity Protein-containing Complex Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding Protein Phosphatase 1 Binding Myosin Phosphatase Regulator Activity Protein Phosphatase Regulator Activity
	Biological Process	Brain Development TRNA Methylthiolation Regulation Of Neuron Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Translational Fidelity Positive Regulation Of Mitochondrial Translation Mitochondrial TRNA Modification	Positive Regulation Of Endothelial Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Protein Dephosphorylation Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Filopodium Assembly Establishment Of Endothelial Barrier Negative Regulation Of Peptidyl-serine Dephosphorylation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis
Pathways
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Hip circumference adjusted for BMI ( 25673412) Mean corpuscular volume ( 32888494)	Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis ( 28714907) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diverticular disease ( 30177863) Huntington's disease progression ( 28642124) Mean corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		4 interacting genes: CDK5 CDK5R1 EXOSC3 EXOSC5	37 interacting genes: ATPAF2 CDCA7L CEP55 CEP70 CRX DVL2 DVL3 FAM83A FARS2 FLYWCH1 GATA1 GFAP GOLGA2 HAPLN2 IKZF3 KCTD9 MAGOH MISP NEFL PATZ1 PHC2 PLEKHN1 PPP1CA PPP1CB RBPMS RFC5 SCNM1 SF3B4 SHC3 TACO1 TADA2A TASOR2 TFIP11 TLE5 TXN2 ZNF410 ZNF564
Entrez ID		51654	26051
HPRD ID		12189	15168
Ensembl ID		ENSG00000101391	ENSG00000101445
Uniprot IDs		A0A0S2Z592 A0A0S2Z5J9 Q53H36 Q96SZ6	Q96T49
PDB IDs
Enriched GO Terms of Interacting Partners?
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