ATP6V1H and ETHE1

Data Source:
HPRD (two hybrid)

		ATP6V1H	ETHE1
Description		ATPase H+ transporting V1 subunit H	ETHE1 persulfide dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Lysosomal Membrane Cytosol Plasma Membrane Extracellular Exosome	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding ATPase Activity Enzyme Regulator Activity Proton-transporting ATPase Activity, Rotational Mechanism	Iron Ion Binding Protein Binding Hydrolase Activity, Acting On Ester Bonds Identical Protein Binding Sulfur Dioxygenase Activity
	Biological Process	Endocytosis Vacuolar Acidification Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Regulation Of Defense Response To Virus By Virus Regulation Of Catalytic Activity Phagosome Acidification Proton Transmembrane Transport	Glutathione Metabolic Process Sulfide Oxidation, Using Sulfide:quinone Oxidoreductase Hydrogen Sulfide Metabolic Process
Pathways		ROS and RNS production in phagocytes Nef Mediated CD4 Down-regulation Nef Mediated CD8 Down-regulation Insulin receptor recycling Transferrin endocytosis and recycling Blockage of phagosome acidification Amino acids regulate mTORC1 Ion channel transport	Sulfide oxidation to sulfate
Drugs		Tiludronic acid
Diseases
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		10 interacting genes: ATP6V1E1 CDKN2B ETHE1 FLACC1 PPP1R12C SNPH SOX9 SPATA2 TANK TRIM14	9 interacting genes: APP ATG9A ATP6V1H GORASP2 IGSF21 KRTAP19-2 LRIF1 RELA TXN2
Entrez ID		51606	23474
HPRD ID		10591	09764
Ensembl ID		ENSG00000047249	ENSG00000105755
Uniprot IDs		A0A024R7U9 A0A024R7X3 B3KUZ7 Q9UI12	A0A0S2Z580 A0A0S2Z5B3 A0A0S2Z5N8 B2RCZ7 O95571
PDB IDs			4CHL
Enriched GO Terms of Interacting Partners?
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