ATP6V1H and TANK

Data Source:
BioGRID (two hybrid)

		ATP6V1H	TANK
Description		ATPase H+ transporting V1 subunit H	TRAF family member associated NFKB activator
Image		No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Lysosomal Membrane Cytosol Plasma Membrane Extracellular Exosome	Cytosol Protein-containing Complex
	Molecular Function	Protein Binding ATPase Activity Enzyme Regulator Activity Proton-transporting ATPase Activity, Rotational Mechanism	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity Metal Ion Binding
	Biological Process	Endocytosis Vacuolar Acidification Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Regulation Of Defense Response To Virus By Virus Regulation Of Catalytic Activity Phagosome Acidification Proton Transmembrane Transport	Proteolysis Cellular Response To DNA Damage Stimulus Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Viral Process Protein Phosphopantetheinylation TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Ionizing Radiation Positive Regulation Of Protein Deubiquitination Positive Regulation Of Ubiquitin-specific Protease Activity
Pathways		ROS and RNS production in phagocytes Nef Mediated CD4 Down-regulation Nef Mediated CD8 Down-regulation Insulin receptor recycling Transferrin endocytosis and recycling Blockage of phagosome acidification Amino acids regulate mTORC1 Ion channel transport	TICAM1-dependent activation of IRF3/IRF7 TRAF6 mediated IRF7 activation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs		Tiludronic acid
Diseases
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Alcohol consumption ( 27911795) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Dietary macronutrient intake ( 23372041) Educational attainment ( 25201988) Educational attainment (years of education) ( 23722424) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Presence of antiphospholipid antibodies ( 23509613) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Subcutaneous adipose tissue ( 22589738) Tourette syndrome ( 30818990) Treatment response for severe sepsis ( 22310353) Weight ( 31647587)
Interacting Genes		10 interacting genes: ATP6V1E1 CDKN2B ETHE1 FLACC1 PPP1R12C SNPH SOX9 SPATA2 TANK TRIM14	31 interacting genes: AIMP2 APBA3 APP ATP6V1H BIK CD40 CHUK COPB1 FBLN1 HLA-C IKBKB IKBKE IKBKG INPP5K KPNA2 LAMC1 MAP4K5 MARCHF5 PLK1 RACGAP1 SDC4 SMAD3 SRSF11 TBK1 TP53BP2 TRAF1 TRAF2 TRAF3 TRAF6 USP7 ZC3H12A
Entrez ID		51606	10010
HPRD ID		10591	04870
Ensembl ID		ENSG00000047249	ENSG00000136560
Uniprot IDs		A0A024R7U9 A0A024R7X3 B3KUZ7 Q9UI12	B2R7S3 Q6NW12 Q92844
PDB IDs			1KZZ 1L0A 5H10
Enriched GO Terms of Interacting Partners?
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