CYRIB and HIP1

Data Source:
BioGRID (two hybrid)

		CYRIB	HIP1
Description		CYFIP related Rac1 interactor B	huntingtin interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Cilium Membrane Platelet Alpha Granule Lumen Extracellular Exosome	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Intracellular Membrane-bounded Organelle Presynapse Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding MHC Class Ib Protein Binding, Via Antigen Binding Groove Small GTPase Binding	Epidermal Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Glutamate Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Platelet Degranulation Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Activation Regulation Of Chemotaxis Negative Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Molecule Of Bacterial Origin Regulation Of Mitochondrial Fission Regulation Of Establishment Of Cell Polarity Positive Regulation Of Memory T Cell Activation	Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Protein Kinase B Signaling Membrane Organization Clathrin-dependent Endocytosis Apoptotic Signaling Pathway Neurotransmitter Receptor Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Platelet degranulation	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Age-related nuclear cataracts ( 24951543) Alcoholism (12-month weekly alcohol consumption) ( 21529783) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26961502 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Interleukin-6 levels ( 22205395) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)
Interacting Genes		3 interacting genes: HIP1 MAPK6 NIF3L1	37 interacting genes: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CFAP53 CLTA CLTB CLTC CYRIB DAZAP2 DVL2 EHHADH EIF6 FAM168A FBXO25 GLS2 HIP1R HTT IFT57 ITSN1 LITAF LNX1 MAP3K1 MAPK6 NECAP1 PFDN1 RAD23B REL RPRM RPS10 SMURF1 SYT17 TCEA2 TCEANC TFAP2A
Entrez ID		51571	3092
HPRD ID		13313	03461
Ensembl ID		ENSG00000153310	ENSG00000127946
Uniprot IDs		A0A024R9G4 Q9NUQ9	B4DK46 O00291
PDB IDs			2NO2 2QA7 3I00
Enriched GO Terms of Interacting Partners?
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