HIP1 and CLTA

Data Source:
HPRD (in vitro)

		HIP1	CLTA
Description		huntingtin interacting protein 1	clathrin light chain A
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Intracellular Membrane-bounded Organelle Presynapse Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse	Spindle Cytosol Plasma Membrane Membrane Clathrin Coat Clathrin Vesicle Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Synaptic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Endolysosome Membrane Clathrin-coated Endocytic Vesicle Clathrin Complex Presynaptic Endocytic Zone Membrane Postsynaptic Endocytic Zone Cytoplasmic Component
	Molecular Function	Epidermal Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Glutamate Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding	Molecular_function Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding Protein-containing Complex Binding GTPase Binding
	Biological Process	Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Protein Kinase B Signaling Membrane Organization Clathrin-dependent Endocytosis Apoptotic Signaling Pathway Neurotransmitter Receptor Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Intracellular Protein Transport Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Clathrin Coat Assembly Cell Division Membrane Organization Clathrin-dependent Endocytosis
Pathways		Clathrin-mediated endocytosis	Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Alcoholism (12-month weekly alcohol consumption) ( 21529783) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26961502 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Interleukin-6 levels ( 22205395) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)
Interacting Genes		37 interacting genes: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CFAP53 CLTA CLTB CLTC CYRIB DAZAP2 DVL2 EHHADH EIF6 FAM168A FBXO25 GLS2 HIP1R HTT IFT57 ITSN1 LITAF LNX1 MAP3K1 MAPK6 NECAP1 PFDN1 RAD23B REL RPRM RPS10 SMURF1 SYT17 TCEA2 TCEANC TFAP2A	8 interacting genes: CLTC EGFR HIP1 HIP1R HSPA8 MAP1LC3B RGS2 SYNJ1
Entrez ID		3092	1211
HPRD ID		03461	00351
Ensembl ID		ENSG00000127946	ENSG00000122705
Uniprot IDs		B4DK46 O00291	C9J8P9 P09496
PDB IDs		2NO2 2QA7 3I00	6E5N
Enriched GO Terms of Interacting Partners?
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